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RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.
Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H. Kawata K, et al. Among authors: nakayama m. J Med Chem. 2015 Jan 22;58(2):912-26. doi: 10.1021/jm501863r. Epub 2014 Dec 17. J Med Chem. 2015. PMID: 25486327
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
Ohsawa F, Yamada S, Yakushiji N, Shinozaki R, Nakayama M, Kawata K, Hagaya M, Kobayashi T, Kohara K, Furusawa Y, Fujiwara C, Ohta Y, Makishima M, Naitou H, Tai A, Yoshikawa Y, Yasui H, Kakuta H. Ohsawa F, et al. Among authors: nakayama m. J Med Chem. 2013 Mar 14;56(5):1865-77. doi: 10.1021/jm400033f. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23391145
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
Kakuta H, Yakushiji N, Shinozaki R, Ohsawa F, Yamada S, Ohta Y, Kawata K, Nakayama M, Hagaya M, Fujiwara C, Makishima M, Uno S, Tai A, Maehara A, Nakayama M, Oohashi T, Yasui H, Yoshikawa Y. Kakuta H, et al. Among authors: nakayama m. ACS Med Chem Lett. 2012 Apr 9;3(5):427-32. doi: 10.1021/ml300055n. eCollection 2012 May 10. ACS Med Chem Lett. 2012. PMID: 24900488 Free PMC article.
Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes.
Murakami Y, Shimizu Y, Ogasawara A, Ueshima S, Nakayama M, Kawata K, Kakuta H, Aiba T. Murakami Y, et al. Among authors: nakayama m. Drug Dev Ind Pharm. 2014 Aug;40(8):1065-71. doi: 10.3109/03639045.2013.807278. Epub 2013 Jun 19. Drug Dev Ind Pharm. 2014. PMID: 23781857
Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes.
Collet C, Munhoz D, Mizukami T, Sonck J, Matsuo H, Shinke T, Ando H, Ko B, Biscaglia S, Rivero F, Engstrøm T, Arslani K, Leone AM, van Nunen LX, Fearon WF, Christiansen EH, Fournier S, Desta L, Yong A, Adjej J, Escaned J, Nakayama M, Eftekhari A, Zimmermann FM, Sakai K, Storozhenko T, da Costa BR, Campo G, West NEJ, De Potter T, Heggermont W, Buytaert D, Bartunek J, Berry C, Collison D, Johnson T, Amano T, Perera D, Jeremias A, Ali Z, Pijls NHJ, De Bruyne B, Johnson NP. Collet C, et al. Among authors: nakayama m. Circulation. 2024 May 14. doi: 10.1161/CIRCULATIONAHA.124.069450. Online ahead of print. Circulation. 2024. PMID: 38742491
J-AVENUE: A retrospective, real-world study evaluating patient characteristics and outcomes in patients with advanced urothelial carcinoma treated with avelumab first-line maintenance therapy in Japan.
Kikuchi E, Hayakawa N, Nakayama M, Uno M, Nakatsu H, Kitagawa C, Miyake H, Yamada T, Fujita K, Shimoyama H, Nishihara K, Kobayashi M, Nakamura M, Fujimoto K, Sano T, Nishiyama N, Ito T, Kajita M, Kobayashi T, Kitamura H. Kikuchi E, et al. Among authors: nakayama m. Int J Urol. 2024 May 9. doi: 10.1111/iju.15473. Online ahead of print. Int J Urol. 2024. PMID: 38722221
3,250 results