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Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.
Poo YS, Rudd PA, Gardner J, Wilson JA, Larcher T, Colle MA, Le TT, Nakaya HI, Warrilow D, Allcock R, Bielefeldt-Ohmann H, Schroder WA, Khromykh AA, Lopez JA, Suhrbier A. Poo YS, et al. Among authors: nakaya hi. PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3354. doi: 10.1371/journal.pntd.0003354. eCollection 2014 Dec. PLoS Negl Trop Dis. 2014. PMID: 25474568 Free PMC article.
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Chen W, et al. Among authors: nakaya hi. Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28. Nat Microbiol. 2017. PMID: 28848230
Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.
Prow NA, Tang B, Gardner J, Le TT, Taylor A, Poo YS, Nakayama E, Hirata TDC, Nakaya HI, Slonchak A, Mukhopadhyay P, Mahalingam S, Schroder WA, Klimstra W, Suhrbier A. Prow NA, et al. Among authors: nakaya hi. PLoS Pathog. 2017 Dec 27;13(12):e1006788. doi: 10.1371/journal.ppat.1006788. eCollection 2017 Dec. PLoS Pathog. 2017. PMID: 29281739 Free PMC article.
Systems analysis of subjects acutely infected with the Chikungunya virus.
Soares-Schanoski A, Baptista Cruz N, de Castro-Jorge LA, de Carvalho RVH, Santos CAD, Rós ND, Oliveira Ú, Costa DD, Santos CLSD, Cunha MDP, Oliveira MLS, Alves JC, Océa RALC, Ribeiro DR, Gonçalves ANA, Gonzalez-Dias P, Suhrbier A, Zanotto PMA, Azevedo IJ, Zamboni DS, Almeida RP, Ho PL, Kalil J, Nishiyama MY Junior, Nakaya HI. Soares-Schanoski A, et al. Among authors: nakaya hi. PLoS Pathog. 2019 Jun 18;15(6):e1007880. doi: 10.1371/journal.ppat.1007880. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31211814 Free PMC article. Clinical Trial.
Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.
de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI, Nakaya HI. de Lima DS, et al. Among authors: nakaya hi. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17121-17126. doi: 10.1073/pnas.1822046116. Epub 2019 Aug 9. Proc Natl Acad Sci U S A. 2019. PMID: 31399544 Free PMC article.
175 results