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The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.
Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, Zeng L, Nan J, Seo G, Vargas RE, Yang B, Qi R, Bardwell L, Fishman DA, Cho KWY, Huang L, Luo R, Warrior R, Wang W. Han H, et al. Among authors: nakaoka hj. Nat Cell Biol. 2022 Jan;24(1):74-87. doi: 10.1038/s41556-021-00813-8. Epub 2022 Jan 13. Nat Cell Biol. 2022. PMID: 35027733 Free PMC article.
Hippo signaling dysfunction induces cancer cell addiction to YAP.
Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, Le Nguyen K, Bishara AT, Mandalia TK, Wang W. Han H, et al. Among authors: nakaoka hj. Oncogene. 2018 Dec;37(50):6414-6424. doi: 10.1038/s41388-018-0419-5. Epub 2018 Aug 1. Oncogene. 2018. PMID: 30068939 Free PMC article.
Defining the ATPome reveals cross-optimization of metabolic pathways.
Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. Bennett NK, et al. Among authors: nakaoka hj. Nat Commun. 2020 Aug 28;11(1):4319. doi: 10.1038/s41467-020-18084-6. Nat Commun. 2020. PMID: 32859923 Free PMC article.
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