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Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways.
Dias GF, Bonan NB, Steiner TM, Tozoni SS, Rodrigues S, Nakao LS, Kuntsevich V, Pecoits Filho R, Kotanko P, Moreno-Amaral AN. Dias GF, et al. Among authors: nakao ls. Toxins (Basel). 2018 Jul 5;10(7):280. doi: 10.3390/toxins10070280. Toxins (Basel). 2018. PMID: 29976888 Free PMC article.
Uremic toxins promote accumulation of oxidized protein and increased sensitivity to hydrogen peroxide in endothelial cells by impairing the autophagic flux.
Rodrigues SD, Santos SS, Meireles T, Romero N, Glorieux G, Pecoits-Filho R, Zhang DD, Nakao LS. Rodrigues SD, et al. Among authors: nakao ls. Biochem Biophys Res Commun. 2020 Feb 26;523(1):123-129. doi: 10.1016/j.bbrc.2019.12.022. Epub 2019 Dec 16. Biochem Biophys Res Commun. 2020. PMID: 31837804 Free article.
Oxidation of apoptosis-inducing factor (AIF) to disulfide-linked conjugates.
Lo SM, Martinez PA, Marques EF, Miyamoto S, Valdameri G, Moure VR, Zanata SM, Nakao LS. Lo SM, et al. Among authors: nakao ls. Arch Biochem Biophys. 2020 Oct 15;692:108515. doi: 10.1016/j.abb.2020.108515. Epub 2020 Aug 10. Arch Biochem Biophys. 2020. PMID: 32791141 Free article.
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