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Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY. Tobe BTD, et al. Among authors: nakamura h, nakamura f. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4462-E4471. doi: 10.1073/pnas.1700111114. Epub 2017 May 12. Proc Natl Acad Sci U S A. 2017. PMID: 28500272 Free PMC article.
Quantitative analysis of intraneuronal transport in human iPS neurons.
Nakamura H, Yamashita N, Kanamaru Y, Tachibana T, Sekino Y, Chen S, Gotoh T, Tanaka F, Goshima Y. Nakamura H, et al. J Pharmacol Sci. 2015 Aug;128(4):170-8. doi: 10.1016/j.jphs.2015.06.006. Epub 2015 Jun 27. J Pharmacol Sci. 2015. PMID: 26232861 Free article.
CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development.
Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y. Makihara H, et al. Among authors: nakamura h, nakamura f. Genes Cells. 2016 Sep;21(9):994-1005. doi: 10.1111/gtc.12399. Epub 2016 Aug 2. Genes Cells. 2016. PMID: 27480924 Free article.
Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice.
Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, Kawamoto Y, Jitsuki-Takahashi A, Yonezaki K, Takase K, Miyazaki T, Nakamura F, Tanaka F, Goshima Y. Nakamura H, et al. Among authors: nakamura f. Genes Cells. 2016 Oct;21(10):1059-1079. doi: 10.1111/gtc.12403. Epub 2016 Sep 1. Genes Cells. 2016. PMID: 27582038 Free article.
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.
Aladeokin AC, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H, Nakamura F, Saito T, Saido T, Goshima Y. Aladeokin AC, et al. Among authors: nakamura h, nakamura f. Neurobiol Dis. 2019 Dec;132:104603. doi: 10.1016/j.nbd.2019.104603. Epub 2019 Sep 5. Neurobiol Dis. 2019. PMID: 31494281 Free article.
Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia.
Nomoto M, Konopaske GT, Yamashita N, Aoki R, Jitsuki-Takahashi A, Nakamura H, Makihara H, Saito M, Saigusa Y, Nakamura F, Watanabe K, Baba T, Benes FM, Tobe BTD, Pernia CD, Coyle JT, Sidman RL, Hirayasu Y, Snyder EY, Goshima Y. Nomoto M, et al. Among authors: nakamura h, nakamura f. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2100032118. doi: 10.1073/pnas.2100032118. Proc Natl Acad Sci U S A. 2021. PMID: 34330827 Free PMC article.
Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice.
Asano T, Nakamura H, Kawamoto Y, Tada M, Kimura Y, Takano H, Yao R, Saito H, Ikeda T, Komiya H, Kubota S, Hashiguchi S, Takahashi K, Kunii M, Tanaka K, Goshima Y, Nakamura F, Takeuchi H, Doi H, Tanaka F. Asano T, et al. Among authors: nakamura h, nakamura f. eNeuro. 2022 May 23;9(3):ENEURO.0133-22.2022. doi: 10.1523/ENEURO.0133-22.2022. Print 2022 May-Jun. eNeuro. 2022. PMID: 35523582 Free PMC article.
Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis.
Kawamoto Y, Tada M, Asano T, Nakamura H, Jitsuki-Takahashi A, Makihara H, Kubota S, Hashiguchi S, Kunii M, Ohshima T, Goshima Y, Takeuchi H, Doi H, Nakamura F, Tanaka F. Kawamoto Y, et al. Among authors: nakamura h, nakamura f. Front Neurol. 2022 Sep 27;13:994676. doi: 10.3389/fneur.2022.994676. eCollection 2022. Front Neurol. 2022. PMID: 36237616 Free PMC article.
SGTA associates with intracellular aggregates in neurodegenerative diseases.
Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F. Kubota S, et al. Among authors: nakamura h. Mol Brain. 2021 Mar 23;14(1):59. doi: 10.1186/s13041-021-00770-1. Mol Brain. 2021. PMID: 33757575 Free PMC article.
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