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Patritumab deruxtecan (HER3-DXd), a novel HER3 directed antibody drug conjugate, exhibits in vitro activity against breast cancer cells expressing HER3 mutations with and without HER2 overexpression.
Koyama K, Ishikawa H, Abe M, Shiose Y, Ueno S, Qiu Y, Nakamaru K, Murakami M. Koyama K, et al. Among authors: nakamaru k. PLoS One. 2022 May 3;17(5):e0267027. doi: 10.1371/journal.pone.0267027. eCollection 2022. PLoS One. 2022. PMID: 35503762 Free PMC article.
Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.
Mendell J, Freeman DJ, Feng W, Hettmann T, Schneider M, Blum S, Ruhe J, Bange J, Nakamaru K, Chen S, Tsuchihashi Z, von Pawel J, Copigneaux C, Beckman RA. Mendell J, et al. Among authors: nakamaru k. EBioMedicine. 2015 Feb 12;2(3):264-71. doi: 10.1016/j.ebiom.2015.02.005. eCollection 2015 Mar. EBioMedicine. 2015. PMID: 26137564 Free PMC article. Clinical Trial.
Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition.
Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, Zhao R, Heese L, Ma W, Ma MCJ, DiNardo C, Pierce S, Patel KP, Tse A, Davis RE, Rao A, Andreeff M. Ishizawa J, et al. Among authors: nakamaru k. Cancer Res. 2018 May 15;78(10):2721-2731. doi: 10.1158/0008-5472.CAN-17-0949. Epub 2018 Feb 28. Cancer Res. 2018. PMID: 29490944 Free PMC article.
NTRK3 kinase fusions in Spitz tumours.
Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. Yeh I, et al. Among authors: nakamaru k. J Pathol. 2016 Nov;240(3):282-290. doi: 10.1002/path.4775. J Pathol. 2016. PMID: 27477320 Free PMC article.
Real-Time Reverse-Transcription Quantitative Polymerase Chain Reaction Assay Is a Feasible Method for the Relative Quantification of Heregulin Expression in Non-Small Cell Lung Cancer Tissue.
Kristof J, Sakrison K, Jin X, Nakamaru K, Schneider M, Beckman RA, Freeman D, Spittle C, Feng W. Kristof J, et al. Among authors: nakamaru k. Biomark Insights. 2017 Mar 30;12:1177271917699850. doi: 10.1177/1177271917699850. eCollection 2017. Biomark Insights. 2017. PMID: 28469400 Free PMC article.
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors.
Papadopoulos KP, Borazanci E, Shaw AT, Katayama R, Shimizu Y, Zhu VW, Sun TY, Wakelee HA, Madison R, Schrock AB, Senaldi G, Nakao N, Hanzawa H, Tachibana M, Isoyama T, Nakamaru K, Deng C, Li M, Fan F, Zhao Q, Gao Y, Seto T, Jänne PA, Ou SI. Papadopoulos KP, et al. Among authors: nakamaru k. Clin Cancer Res. 2020 Sep 15;26(18):4785-4794. doi: 10.1158/1078-0432.CCR-20-1630. Epub 2020 Jun 26. Clin Cancer Res. 2020. PMID: 32591465 Clinical Trial.
Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.
Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M. Min KD, et al. Among authors: nakamaru k. Biochem Biophys Res Commun. 2010 Feb 26;393(1):55-60. doi: 10.1016/j.bbrc.2010.01.076. Epub 2010 Jan 25. Biochem Biophys Res Commun. 2010. PMID: 20100464
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.
Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M. Seguchi O, et al. Among authors: nakamaru k. J Clin Invest. 2007 Oct;117(10):2812-24. doi: 10.1172/JCI30804. J Clin Invest. 2007. PMID: 17885681 Free PMC article.
59 results