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Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.
Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H. Han SI, et al. Among authors: nakakuki m. PNAS Nexus. 2023 Nov 8;2(11):pgad351. doi: 10.1093/pnasnexus/pgad351. eCollection 2023 Nov. PNAS Nexus. 2023. PMID: 37954160 Free PMC article.
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N. Kato T, et al. Among authors: nakakuki m. Diabetes. 2008 Sep;57(9):2382-92. doi: 10.2337/db06-1806. Epub 2008 May 5. Diabetes. 2008. PMID: 18458149 Free PMC article.
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N. Yamamoto T, et al. Among authors: nakakuki m. J Biol Chem. 2004 Mar 26;279(13):12027-35. doi: 10.1074/jbc.M310333200. Epub 2004 Jan 13. J Biol Chem. 2004. PMID: 14722127 Free article.
SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N. Ide T, et al. Among authors: nakakuki m. Nat Cell Biol. 2004 Apr;6(4):351-7. doi: 10.1038/ncb1111. Epub 2004 Mar 14. Nat Cell Biol. 2004. PMID: 15048126
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H. Kumadaki S, et al. Among authors: nakakuki m. J Biol Chem. 2011 Nov 25;286(47):40835-46. doi: 10.1074/jbc.M111.235283. Epub 2011 Sep 12. J Biol Chem. 2011. PMID: 21911492 Free PMC article.
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N. Yoshikawa T, et al. Among authors: nakakuki m. J Biol Chem. 2002 Jan 18;277(3):1705-11. doi: 10.1074/jbc.M105711200. Epub 2001 Nov 2. J Biol Chem. 2002. PMID: 11694526 Free article.
73 results