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Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism.
Nakajima T, Tanaka N, Kanbe H, Hara A, Kamijo Y, Zhang X, Gonzalez FJ, Aoyama T. Nakajima T, et al. Mol Pharmacol. 2009 Apr;75(4):782-92. doi: 10.1124/mol.108.052928. Epub 2009 Jan 5. Mol Pharmacol. 2009. PMID: 19124612 Free PMC article.
Down-regulation of SREBP-1c is associated with the development of burned-out NASH.
Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Nakayama J, Tanaka E, Aoyama T. Nagaya T, et al. Among authors: nakajima t. J Hepatol. 2010 Oct;53(4):724-31. doi: 10.1016/j.jhep.2010.04.033. Epub 2010 Jul 1. J Hepatol. 2010. PMID: 20655124
Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration.
Takahashi K, Kamijo Y, Hora K, Hashimoto K, Higuchi M, Nakajima T, Ehara T, Shigematsu H, Gonzalez FJ, Aoyama T. Takahashi K, et al. Among authors: nakajima t. Toxicol Appl Pharmacol. 2011 May 1;252(3):237-49. doi: 10.1016/j.taap.2011.02.012. Epub 2011 Feb 19. Toxicol Appl Pharmacol. 2011. PMID: 21338618 Free PMC article.
5,890 results