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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.
Villa-Pérez P, Merino B, Fernández-Díaz CM, Cidad P, Lobatón CD, Moreno A, Muturi HT, Ghadieh HE, Najjar SM, Leissring MA, Cózar-Castellano I, Perdomo G. Villa-Pérez P, et al. Among authors: najjar sm. Metabolism. 2018 Nov;88:1-11. doi: 10.1016/j.metabol.2018.08.001. Epub 2018 Aug 8. Metabolism. 2018. PMID: 30098324 Free PMC article.
Hepatic Insulin Clearance: Mechanism and Physiology.
Najjar SM, Perdomo G. Najjar SM, et al. Physiology (Bethesda). 2019 May 1;34(3):198-215. doi: 10.1152/physiol.00048.2018. Physiology (Bethesda). 2019. PMID: 30968756 Free PMC article. Review.
Loss of Ceacam1 promotes prostate cancer progression in Pten haploinsufficient male mice.
Liu J, Muturi HT, Khuder SS, Helal RA, Ghadieh HE, Ramakrishnan SK, Kaw MK, Lester SG, Al-Khudhair A, Conran PB, Chin KV, Gatto-Weis C, Najjar SM. Liu J, et al. Among authors: najjar sm. Metabolism. 2020 Jun;107:154215. doi: 10.1016/j.metabol.2020.154215. Epub 2020 Mar 21. Metabolism. 2020. PMID: 32209360 Free PMC article.
Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease.
Heinrich G, Ghadieh HE, Ghanem SS, Muturi HT, Rezaei K, Al-Share QY, Bowman TA, Zhang D, Garofalo RS, Yin L, Najjar SM. Heinrich G, et al. Among authors: najjar sm. Front Endocrinol (Lausanne). 2017 Jan 26;8:8. doi: 10.3389/fendo.2017.00008. eCollection 2017. Front Endocrinol (Lausanne). 2017. PMID: 28184213 Free PMC article. Review.
129 results