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RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.
Xiong HY, Alipanahi B, Lee LJ, Bretschneider H, Merico D, Yuen RK, Hua Y, Gueroussov S, Najafabadi HS, Hughes TR, Morris Q, Barash Y, Krainer AR, Jojic N, Scherer SW, Blencowe BJ, Frey BJ. Xiong HY, et al. Among authors: najafabadi hs. Science. 2015 Jan 9;347(6218):1254806. doi: 10.1126/science.1254806. Epub 2014 Dec 18. Science. 2015. PMID: 25525159 Free PMC article.
A compendium of RNA-binding motifs for decoding gene regulation.
Ray D, Kazan H, Cook KB, Weirauch MT, Najafabadi HS, Li X, Gueroussov S, Albu M, Zheng H, Yang A, Na H, Irimia M, Matzat LH, Dale RK, Smith SA, Yarosh CA, Kelly SM, Nabet B, Mecenas D, Li W, Laishram RS, Qiao M, Lipshitz HD, Piano F, Corbett AH, Carstens RP, Frey BJ, Anderson RA, Lynch KW, Penalva LO, Lei EP, Fraser AG, Blencowe BJ, Morris QD, Hughes TR. Ray D, et al. Among authors: najafabadi hs. Nature. 2013 Jul 11;499(7457):172-7. doi: 10.1038/nature12311. Nature. 2013. PMID: 23846655 Free PMC article.
Determination and inference of eukaryotic transcription factor sequence specificity.
Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, Walhout AJM, Bouget FY, Ratsch G, Larrondo LF, Ecker JR, Hughes TR. Weirauch MT, et al. Among authors: najafabadi hs. Cell. 2014 Sep 11;158(6):1431-1443. doi: 10.1016/j.cell.2014.08.009. Cell. 2014. PMID: 25215497 Free PMC article.
C2H2 zinc finger proteins greatly expand the human regulatory lexicon.
Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. Najafabadi HS, et al. Nat Biotechnol. 2015 May;33(5):555-62. doi: 10.1038/nbt.3128. Epub 2015 Feb 18. Nat Biotechnol. 2015. PMID: 25690854
Motif comparison based on similarity of binding affinity profiles.
Lambert SA, Albu M, Hughes TR, Najafabadi HS. Lambert SA, et al. Among authors: najafabadi hs. Bioinformatics. 2016 Nov 15;32(22):3504-3506. doi: 10.1093/bioinformatics/btw489. Epub 2016 Jul 27. Bioinformatics. 2016. PMID: 27466627 Free PMC article.
Multiparameter functional diversity of human C2H2 zinc finger proteins.
Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Schmitges FW, et al. Among authors: najafabadi hs. Genome Res. 2016 Dec;26(12):1742-1752. doi: 10.1101/gr.209643.116. Epub 2016 Nov 16. Genome Res. 2016. PMID: 27852650 Free PMC article.
63 results