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Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
Toba S, Sato A, Kawai M, Taoda Y, Unoh Y, Kusakabe S, Nobori H, Uehara S, Uemura K, Taniguchi K, Kobayashi M, Noshi T, Yoshida R, Naito A, Shishido T, Maruyama J, Paessler S, Carr MJ, Hall WW, Yoshimatsu K, Arikawa J, Matsuno K, Sakoda Y, Sasaki M, Orba Y, Sawa H, Kida H. Toba S, et al. Among authors: naito a. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206104119. doi: 10.1073/pnas.2206104119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037386 Free PMC article.
Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae.
Onishi M, Kitano M, Taniguchi K, Homma T, Kobayashi M, Yoshinaga T, Naito A, Sato A. Onishi M, et al. Among authors: naito a. Antiviral Res. 2015 May;117:52-9. doi: 10.1016/j.antiviral.2015.02.012. Epub 2015 Mar 6. Antiviral Res. 2015. PMID: 25752738
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Noshi T, Kitano M, Taniguchi K, Yamamoto A, Omoto S, Baba K, Hashimoto T, Ishida K, Kushima Y, Hattori K, Kawai M, Yoshida R, Kobayashi M, Yoshinaga T, Sato A, Okamatsu M, Sakoda Y, Kida H, Shishido T, Naito A. Noshi T, et al. Among authors: naito a. Antiviral Res. 2018 Dec;160:109-117. doi: 10.1016/j.antiviral.2018.10.008. Epub 2018 Oct 11. Antiviral Res. 2018. PMID: 30316915 Free article.
Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection.
Fukao K, Noshi T, Yamamoto A, Kitano M, Ando Y, Noda T, Baba K, Matsumoto K, Higuchi N, Ikeda M, Shishido T, Naito A. Fukao K, et al. Among authors: naito a. J Antimicrob Chemother. 2019 Mar 1;74(3):654-662. doi: 10.1093/jac/dky462. J Antimicrob Chemother. 2019. PMID: 30476172 Free PMC article.
Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
Fukao K, Ando Y, Noshi T, Kitano M, Noda T, Kawai M, Yoshida R, Sato A, Shishido T, Naito A. Fukao K, et al. Among authors: naito a. PLoS One. 2019 May 20;14(5):e0217307. doi: 10.1371/journal.pone.0217307. eCollection 2019. PLoS One. 2019. PMID: 31107922 Free PMC article.
The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets.
Kitano M, Matsuzaki T, Oka R, Baba K, Noda T, Yoshida Y, Sato K, Kiyota K, Mizutare T, Yoshida R, Sato A, Kamimori H, Shishido T, Naito A. Kitano M, et al. Among authors: naito a. Influenza Other Respir Viruses. 2020 Nov;14(6):710-719. doi: 10.1111/irv.12760. Epub 2020 Jun 13. Influenza Other Respir Viruses. 2020. PMID: 32533654 Free PMC article.
Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection.
Ando Y, Noshi T, Sato K, Ishibashi T, Yoshida Y, Hasegawa T, Onishi M, Kitano M, Oka R, Kawai M, Yoshida R, Sato A, Shishido T, Naito A. Ando Y, et al. Among authors: naito a. J Antimicrob Chemother. 2021 Jan 1;76(1):189-198. doi: 10.1093/jac/dkaa393. J Antimicrob Chemother. 2021. PMID: 33035324 Free PMC article.
772 results