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Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.
RNA. 2019 Nov;25(11):1481-1496. doi: 10.1261/rna.066746.118. Epub 2019 Aug 9.
RNA. 2019.
PMID: 31399541
Free PMC article.
Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase.
Li Y, Zhong W, Koay AZ, Ng HQ, Koh-Stenta X, Nah Q, Lim SH, Larsson A, Lescar J, Hill J, Dedon PC, Kang C.
Li Y, et al. Among authors: nah q.
Biomol NMR Assign. 2019 Apr;13(1):49-53. doi: 10.1007/s12104-018-9849-9. Epub 2018 Oct 8.
Biomol NMR Assign. 2019.
PMID: 30298375
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Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.
Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P.
Zhong W, et al. Among authors: nah q.
ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4.
ACS Infect Dis. 2019.
PMID: 30682246
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Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa.
Li Y, Zhong W, Koay AZ, Ng HQ, Nah Q, Wong YH, Hill J, Lescar J, Dedon PC, Kang C.
Li Y, et al. Among authors: nah q.
Biomol NMR Assign. 2019 Oct;13(2):327-332. doi: 10.1007/s12104-019-09900-2. Epub 2019 Jun 7.
Biomol NMR Assign. 2019.
PMID: 31175551
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Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC.
Zhong W, et al. Among authors: nah q.
J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29.
J Med Chem. 2019.
PMID: 31442049
Free PMC article.
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tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum.
Ng CS, Sinha A, Aniweh Y, Nah Q, Babu IR, Gu C, Chionh YH, Dedon PC, Preiser PR.
Ng CS, et al. Among authors: nah q.
Mol Syst Biol. 2018 Oct 4;14(10):e8009. doi: 10.15252/msb.20178009.
Mol Syst Biol. 2018.
PMID: 30287681
Free PMC article.
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