Nagase H - Search Results

1

Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.

Katoh K, Yamamoto N, Ishikawa Y, Irukayama-Tomobe Y, Tanimura R, Saitoh T, Nagumo Y, Kutsumura N, Yanagisawa M, Nagase H. Katoh K, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2022 Mar 1;59:128527. doi: 10.1016/j.bmcl.2022.128527. Epub 2022 Jan 7. Bioorg Med Chem Lett. 2022. PMID: 35007722

2

Syntheses of 10-oxo, 10 alpha-hydroxy, and 10 beta-hydroxy derivatives of a potent kappa-opioid receptor agonist, TRK-820.

Horikiri H, Hirano N, Tanaka Y, Oishi J, Hatakeyama H, Kawamura K, Nagase H. Horikiri H, et al. Among authors: nagase h. Chem Pharm Bull (Tokyo). 2004 Jun;52(6):664-9. doi: 10.1248/cpb.52.664. Chem Pharm Bull (Tokyo). 2004. PMID: 15187385 Free article.

3

Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor.

Fujii H, Narita M, Mizoguchi H, Murachi M, Tanaka T, Kawai K, Tseng LF, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem. 2004 Aug 1;12(15):4133-45. doi: 10.1016/j.bmc.2004.05.024. Bioorg Med Chem. 2004. PMID: 15246090

4

Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept.

Fujii H, Narita M, Mizoguchi H, Hirokawa J, Kawai K, Tanaka T, Tseng LF, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4241-3. doi: 10.1016/j.bmcl.2004.06.004. Bioorg Med Chem Lett. 2004. PMID: 15261278

5

Rational drug design of selective epsilon opioid receptor agonist TAN-821 and antagonist TAN-1014.

Fujii H, Nagase H. Fujii H, et al. Among authors: nagase h. Curr Med Chem. 2006;13(10):1109-18. doi: 10.2174/092986706776360851. Curr Med Chem. 2006. PMID: 16719773 Review.

6

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

Nemoto T, Fujii H, Narita M, Miyoshi K, Nakamura A, Suzuki T, Nagase H. Nemoto T, et al. Among authors: nagase h. Bioorg Med Chem. 2008 Apr 15;16(8):4304-12. doi: 10.1016/j.bmc.2008.02.082. Epub 2008 Feb 29. Bioorg Med Chem. 2008. PMID: 18337104

7

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

Sakami S, Maeda M, Kawai K, Aoki T, Kawamura K, Fujii H, Hasebe K, Nakajima M, Endo T, Ueno S, Ito T, Kamei J, Nagase H. Sakami S, et al. Among authors: nagase h. J Med Chem. 2008 Aug 14;51(15):4404-11. doi: 10.1021/jm701440h. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637671

8

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

Sakami S, Kawai K, Maeda M, Aoki T, Fujii H, Ohno H, Ito T, Saitoh A, Nakao K, Izumimoto N, Matsuura H, Endo T, Ueno S, Natsume K, Nagase H. Sakami S, et al. Among authors: nagase h. Bioorg Med Chem. 2008 Sep 1;16(17):7956-67. doi: 10.1016/j.bmc.2008.07.065. Epub 2008 Jul 29. Bioorg Med Chem. 2008. PMID: 18701308

9

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

Fujii H, Osa Y, Ishihara M, Hanamura S, Nemoto T, Nakajima M, Hasebe K, Mochizuki H, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4978-81. doi: 10.1016/j.bmcl.2008.08.019. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18755589

10

Synthesis of a stable iminium salt and propellane derivatives.

Nagase H, Yamamoto N, Nemoto T, Yoza K, Kamiya K, Hirono S, Momen S, Izumimoto N, Hasebe K, Mochizuki H, Fujii H. Nagase H, et al. J Org Chem. 2008 Oct 17;73(20):8093-6. doi: 10.1021/jo801276z. Epub 2008 Sep 24. J Org Chem. 2008. PMID: 18811203

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