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An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study.
Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K, Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M, Izumi Y. Haji S, et al. Among authors: nagano s. JMIR Res Protoc. 2023 Jan 30;12:e42032. doi: 10.2196/42032. JMIR Res Protoc. 2023. PMID: 36716091 Free PMC article.
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H. Ikenaka K, et al. Among authors: nagano s. Eur J Neurol. 2022 May;29(5):1410-1416. doi: 10.1111/ene.15254. Epub 2022 Feb 6. Eur J Neurol. 2022. PMID: 35128793 Free PMC article.
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Cochrane T, Chary S, Chew S, Zhu H, Wu F, Nestorov I, Graham D, Sun P, McNeill M, Fanning L, Ferguson TA, Fradette S; VALOR and OLE Working Group. Miller TM, et al. N Engl J Med. 2022 Sep 22;387(12):1099-1110. doi: 10.1056/NEJMoa2204705. N Engl J Med. 2022. PMID: 36129998 Free article. Clinical Trial.
piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis.
Abdelhamid RF, Ogawa K, Beck G, Ikenaka K, Takeuchi E, Yasumizu Y, Jinno J, Kimura Y, Baba K, Nagai Y, Okada Y, Saito Y, Murayama S, Mochizuki H, Nagano S. Abdelhamid RF, et al. Among authors: nagano s. Mol Neurobiol. 2022 Mar;59(3):1693-1705. doi: 10.1007/s12035-021-02686-2. Epub 2022 Jan 11. Mol Neurobiol. 2022. PMID: 35015250 Free PMC article.
Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus.
Mitani TT, Beck G, Kido K, Yamashita R, Yonenobu Y, Ogawa T, Saeki C, Okuno T, Nagano S, Morii E, Hasegawa M, Saito Y, Murayama S, Mochizuki H. Mitani TT, et al. Among authors: nagano s. Neuropathology. 2021 Aug;41(4):324-331. doi: 10.1111/neup.12763. Epub 2021 Jul 4. Neuropathology. 2021. PMID: 34219295
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.
Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K. Hayakawa H, et al. Among authors: nagano s. Mov Disord. 2020 Feb;35(2):256-267. doi: 10.1002/mds.27887. Epub 2019 Oct 23. Mov Disord. 2020. PMID: 31643109 Free PMC article.
Alternative mitochondrial quality control mediated by extracellular release.
Choong CJ, Okuno T, Ikenaka K, Baba K, Hayakawa H, Koike M, Yokota M, Doi J, Kakuda K, Takeuchi T, Kuma A, Nakamura S, Nagai Y, Nagano S, Yoshimori T, Mochizuki H. Choong CJ, et al. Among authors: nagano s. Autophagy. 2021 Oct;17(10):2962-2974. doi: 10.1080/15548627.2020.1848130. Epub 2020 Dec 10. Autophagy. 2021. PMID: 33218272 Free PMC article.
630 results