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IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Nachmias B, Khan DH, Voisin V, Mer AS, Thomas GE, Segev N, St-Germain J, Hurren R, Gronda M, Botham A, Wang X, Maclean N, Seneviratne AK, Duong N, Xu C, Arruda A, Orouji E, Algouneh A, Hakem R, Shlush L, Minden MD, Raught B, Bader GD, Schimmer AD. Nachmias B, et al. Leukemia. 2022 May;36(5):1283-1295. doi: 10.1038/s41375-022-01513-4. Epub 2022 Feb 12. Leukemia. 2022. PMID: 35152270 Free PMC article.
Metabolic Flexibility in Leukemia-Adapt or Die.
Nachmias B, Schimmer AD. Nachmias B, et al. Cancer Cell. 2018 Nov 12;34(5):695-696. doi: 10.1016/j.ccell.2018.10.012. Cancer Cell. 2018. PMID: 30423291 Free article.
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Mirali S, Botham A, Voisin V, Xu C, St-Germain J, Sharon D, Hoff FW, Qiu Y, Hurren R, Gronda M, Jitkova Y, Nachmias B, MacLean N, Wang X, Arruda A, Minden MD, Horton TM, Kornblau SM, Chan SM, Bader GD, Raught B, Schimmer AD. Mirali S, et al. Among authors: nachmias b. Sci Transl Med. 2020 Apr 8;12(538):eaaz8264. doi: 10.1126/scitranslmed.aaz8264. Sci Transl Med. 2020. PMID: 32269163
Venetoclax is safe and efficacious in relapsed/refractory AML.
Ganzel C, Ram R, Gural A, Wolach O, Gino-Moor S, Vainstein V, Nachmias B, Apel A, Koren-Michowitz M, Pasvolsky O, Yerushalmi R, Danylesko I, Cohen Y, Peretz G, Moshe Y, Zektser M, Yeganeh S, Rowe JM, Ofran Y. Ganzel C, et al. Among authors: nachmias b. Leuk Lymphoma. 2020 Sep;61(9):2221-2225. doi: 10.1080/10428194.2020.1761964. Epub 2020 May 18. Leuk Lymphoma. 2020. PMID: 32420775
p53 in Acute Myeloid Leukemia-Still a significant other.
Nachmias B, Rund D. Nachmias B, et al. Leuk Lymphoma. 2021 Dec;62(14):3315-3317. doi: 10.1080/10428194.2021.1988592. Epub 2021 Oct 5. Leuk Lymphoma. 2021. PMID: 34608823 No abstract available.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O'Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD. Thomas GE, et al. Among authors: nachmias b. Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9. Epub 2022 Jun 6. Nat Cell Biol. 2022. PMID: 35668135 Free PMC article.
Rituximab, methotrexate, procarbazine and lomustine (R-MPL) for the treatment of primary Central nervous system lymphoma.
Lebel E, Goldschmidt N, Siegal T, Lossos A, Rosenberg S, Makranz C, Linetski E, Gatt ME, Gural A, Saban R, Lavie D, Vainstein V, Zimran E, Avni B, Grisaro S, Shaulov A, Nachmias B. Lebel E, et al. Among authors: nachmias b. Leuk Lymphoma. 2022 Sep;63(9):2102-2108. doi: 10.1080/10428194.2022.2064996. Epub 2022 May 2. Leuk Lymphoma. 2022. PMID: 35491706
47 results