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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: nachbur u. J Biol Chem. 2016 Jan 29;291(5):2547. doi: 10.1074/jbc.A110.216226. J Biol Chem. 2016. PMID: 26826208 Free PMC article. No abstract available.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: nachbur u. J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339290 Free PMC article.
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.
Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J. Wong WW, et al. Among authors: nachbur u. Cell Death Differ. 2010 Mar;17(3):482-7. doi: 10.1038/cdd.2009.178. Epub 2009 Nov 20. Cell Death Differ. 2010. PMID: 19927158
NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
Tran LS, Ying L, D'Costa K, Wray-McCann G, Kerr G, Le L, Allison CC, Ferrand J, Chaudhry H, Emery J, De Paoli A, Colon N, Creed S, Kaparakis-Liaskos M, Como J, Dowling JK, Johanesen PA, Kufer TA, Pedersen JS, Mansell A, Philpott DJ, Elgass KD, Abud HE, Nachbur U, Croker BA, Masters SL, Ferrero RL. Tran LS, et al. Among authors: nachbur u. Nat Commun. 2023 Jun 26;14(1):3804. doi: 10.1038/s41467-023-39487-1. Nat Commun. 2023. PMID: 37365163 Free PMC article.
MLKL deficiency protects against low-grade, sterile inflammation in aged mice.
Tovey Crutchfield EC, Garnish SE, Day J, Anderton H, Chiou S, Hempel A, Hall C, Patel KM, Gangatirkar P, Martin KR, Li Wai Suen CSN, Garnham AL, Kueh AJ, Wicks IP, Silke J, Nachbur U, Samson AL, Murphy JM, Hildebrand JM. Tovey Crutchfield EC, et al. Among authors: nachbur u. Cell Death Differ. 2023 Apr;30(4):1059-1071. doi: 10.1038/s41418-023-01121-4. Epub 2023 Feb 8. Cell Death Differ. 2023. PMID: 36755069 Free PMC article.
48 results