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Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.
Seah C, Breen MS, Rusielewicz T, Bader HN, Xu C, Hunter CJ, McCarthy B, Deans PJM, Chattopadhyay M, Goldberg J, Desarnaud F, Makotkine I, Flory JD, Bierer LM, Staniskyte M; NYSCF Global Stem Cell Array® Team; Noggle SA, Huckins LM, Paull D, Brennand KJ, Yehuda R. Seah C, et al. Nat Neurosci. 2022 Nov;25(11):1434-1445. doi: 10.1038/s41593-022-01161-y. Epub 2022 Oct 20. Nat Neurosci. 2022. PMID: 36266471 Free PMC article.
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants.
Han Y, Tan L, Zhou T, Yang L, Carrau L, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team; Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S. Han Y, et al. Cell Stem Cell. 2022 Oct 6;29(10):1475-1490.e6. doi: 10.1016/j.stem.2022.09.008. Cell Stem Cell. 2022. PMID: 36206731 Free PMC article.
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis.
Clayton BLL, Barbar L, Sapar M, Rusielewicz T, Kalpana K, Migliori B; NYSCF Global Stem Cell Array® Team; Paull D, Brenner K, Moroziewicz D, Sand IK, Casaccia P, Tesar PJ, Fossati V. Clayton BLL, et al. bioRxiv [Preprint]. 2023 Aug 2:2023.08.01.551553. doi: 10.1101/2023.08.01.551553. bioRxiv. 2023. PMID: 37577713 Free PMC article. Preprint.
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.
Ghazizadeh Z, Zhu J, Fattahi F, Tang A, Sun X, Amin S, Tsai SY, Khalaj M, Zhou T, Samuel RM, Zhang T, Ortega FA, Gordillo M, Moroziewicz D; NYSCF Global Stem Cell Array® Team; Paull D, Noggle SA, Xiang JZ, Studer L, Christini DJ, Pitt GS, Evans T, Chen S. Ghazizadeh Z, et al. iScience. 2022 Mar 25;25(4):104153. doi: 10.1016/j.isci.2022.104153. eCollection 2022 Apr 15. iScience. 2022. PMID: 35434558 Free PMC article.
Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection.
Yang L, Han Y, Zhou T, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, Giani AM, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array® Team; Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T, Chen S. Yang L, et al. iScience. 2023 May 29;26(7):107001. doi: 10.1016/j.isci.2023.107001. eCollection 2023 Jul 21. iScience. 2023. PMID: 37534130 Free PMC article.
Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.
Schiff L, Migliori B, Chen Y, Carter D, Bonilla C, Hall J, Fan M, Tam E, Ahadi S, Fischbacher B, Geraschenko A, Hunter CJ, Venugopalan S, DesMarteau S, Narayanaswamy A, Jacob S, Armstrong Z, Ferrarotto P, Williams B, Buckley-Herd G, Hazard J, Goldberg J, Coram M, Otto R, Baltz EA, Andres-Martin L, Pritchard O, Duren-Lubanski A, Daigavane A, Reggio K; NYSCF Global Stem Cell Array® Team; Nelson PC, Frumkin M, Solomon SL, Bauer L, Aiyar RS, Schwarzbach E, Noggle SA, Monsma FJ Jr, Paull D, Berndl M, Yang SJ, Johannesson B. Schiff L, et al. Nat Commun. 2022 Mar 25;13(1):1590. doi: 10.1038/s41467-022-28423-4. Nat Commun. 2022. PMID: 35338121 Free PMC article.
Common genetic variation impacts stress response in the brain.
Seah C, Signer R, Deans M, Bader H, Rusielewicz T, Hicks EM, Young H, Cote A, Townsley K, Xu C, Hunter CJ, McCarthy B, Goldberg J, Dobariya S, Holtzherimer PE, Young KA; NYSCF Global Stem Cell Array® Team; Traumatic Stress Brain Research Group; Noggle SA, Krystal JH, Paull D, Girgenti MJ, Yehuda R, Brennand KJ, Huckins LM. Seah C, et al. bioRxiv [Preprint]. 2023 Dec 28:2023.12.27.573459. doi: 10.1101/2023.12.27.573459. bioRxiv. 2023. PMID: 38234801 Free PMC article. Preprint.