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Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Sonia D, Lashuel HA, Martin AJM, Latapiat V, Matus S, Sardi SP, Wiseman RL, Hetz C. Vidal RL, et al. Mol Ther. 2021 May 5;29(5):1862-1882. doi: 10.1016/j.ymthe.2021.01.033. Epub 2021 Feb 3. Mol Ther. 2021. PMID: 33545358 Free PMC article.
Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease.
Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR 3rd, Wilson AA, Connors LH, Kotton DN, Wiseman RL, Murphy GJ. Giadone RM, et al. Stem Cell Reports. 2020 Aug 11;15(2):515-528. doi: 10.1016/j.stemcr.2020.07.003. Epub 2020 Jul 30. Stem Cell Reports. 2020. PMID: 32735824 Free PMC article.
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Grandjean JMD, et al. Nat Chem Biol. 2020 Oct;16(10):1052-1061. doi: 10.1038/s41589-020-0584-z. Epub 2020 Jul 20. Nat Chem Biol. 2020. PMID: 32690944 Free PMC article.
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.
García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL, Hetz C. García-Huerta P, et al. Acta Neuropathol. 2020 Nov;140(5):737-764. doi: 10.1007/s00401-020-02183-1. Epub 2020 Jul 8. Acta Neuropathol. 2020. PMID: 32642868 Free PMC article.
Proteostasis and Beyond: ATF6 in Ischemic Disease.
Glembotski CC, Rosarda JD, Wiseman RL. Glembotski CC, et al. Trends Mol Med. 2019 Jun;25(6):538-550. doi: 10.1016/j.molmed.2019.03.005. Epub 2019 May 8. Trends Mol Med. 2019. PMID: 31078432 Free PMC article. Review.
15 results