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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 6
1988 10
1989 11
1990 17
1991 16
1992 20
1993 15
1994 14
1995 9
1996 9
1997 7
1998 5
1999 3
2000 7
2001 3
2002 8
2003 5
2004 7
2005 5
2006 6
2007 3
2008 5
2009 7
2010 9
2011 10
2012 7
2013 8
2014 8
2015 7
2016 8
2017 7
2018 34
2019 45
2020 25
2021 28
2022 21
2023 5
2024 4

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390 results

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Page 1
Intercalated cell function, kidney innate immunity, and urinary tract infections.
Schwaderer AL, Rajadhyaksha E, Canas J, Saxena V, Hains DS. Schwaderer AL, et al. Pflugers Arch. 2024 Apr;476(4):565-578. doi: 10.1007/s00424-024-02905-4. Epub 2024 Jan 16. Pflugers Arch. 2024. PMID: 38227050 Review.
Located in the terminal kidney tubule segment, ICs are among the first kidney cells to encounter bacteria when bacteria ascend from the bladder into the kidney. ...Similarly, studies in human children demonstrate that those with history of UTIs are mor …
Located in the terminal kidney tubule segment, ICs are among the first kidney cells to encounter bacteria when bacteria ascend …
From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma.
Lykins J, Moschitto MJ, Zhou Y, Filippova EV, Le HV, Tomita T, Fox BA, Bzik DJ, Su C, Rajagopala SV, Flores K, Spano F, Woods S, Roberts CW, Hua C, El Bissati K, Wheeler KM, Dovgin S, Muench SP, McPhillie M, Fishwick CWG, Anderson WF, Lee PJ, Hickman M, Weiss LM, Dubey JP, Lorenzi HA, Silverman RB, McLeod RL. Lykins J, et al. iScience. 2023 Nov 16;27(1):108477. doi: 10.1016/j.isci.2023.108477. eCollection 2024 Jan 19. iScience. 2023. PMID: 38205261 Free PMC article.
We solve TgO/GABA-AT structures with bound inactivators at 1.55 A and identify an inactivator selective for TgO/GABA-AT over human OAT and GABA-AT. However, abrogating TgO/GABA-AT genetically does not diminish replication, virulence, cyst-formation, or eliminate cat's oocy …
We solve TgO/GABA-AT structures with bound inactivators at 1.55 A and identify an inactivator selective for TgO/GABA-AT over human OA …
Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.
Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M. Wang XX, et al. Am J Pathol. 2023 Dec;193(12):1969-1987. doi: 10.1016/j.ajpath.2023.07.008. Epub 2023 Sep 17. Am J Pathol. 2023. PMID: 37717940
The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR). ...These findings highlight novel druggable pathways that can be further evaluated to prevent progression of age-related kidney dis …
The ERRs were decreased in both aging human and mouse kidneys and were preserved in aging mice with lifelong caloric restriction (CR) …
Cannabidiol negatively modulates adenosine A(2A) receptor functioning in living cells.
Sánchez-Fernández N, Gómez-Acero L, Sarasola LI, Argerich J, Chevigné A, Jacobson KA, Ciruela F, Fernández-Dueñas V, Aso E. Sánchez-Fernández N, et al. Acta Neuropsychiatr. 2023 Aug 22:1-5. doi: 10.1017/neu.2023.30. Online ahead of print. Acta Neuropsychiatr. 2023. PMID: 37605951
The mechanism(s) of action of CBD require further investigation. Previous studies suggested that adenosine A(2A) receptors (A(2A)Rs) could play a role in CBD-induced effects. ...METHODS: We used HEK-293T cells transfected with the cDNA encoding the human A(2A)R and …
The mechanism(s) of action of CBD require further investigation. Previous studies suggested that adenosine A(2A) receptors (A(2A)Rs) …
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits.
Costanzo MC, von Grotthuss M, Massung J, Jang D, Caulkins L, Koesterer R, Gilbert C, Welch RP, Kudtarkar P, Hoang Q, Boughton AP, Singh P, Sun Y, Duby M, Moriondo A, Nguyen T, Smadbeck P, Alexander BR, Brandes M, Carmichael M, Dornbos P, Green T, Huellas-Bruskiewicz KC, Ji Y, Kluge A, McMahon AC, Mercader JM, Ruebenacker O, Sengupta S, Spalding D, Taliun D; AMP-T2D Consortium; Smith P, Thomas MK, Akolkar B, Brosnan MJ, Cherkas A, Chu AY, Fauman EB, Fox CS, Kamphaus TN, Miller MR, Nguyen L, Parsa A, Reilly DF, Ruetten H, Wholley D, Zaghloul NA, Abecasis GR, Altshuler D, Keane TM, McCarthy MI, Gaulton KJ, Florez JC, Boehnke M, Burtt NP, Flannick J. Costanzo MC, et al. Cell Metab. 2023 Apr 4;35(4):695-710.e6. doi: 10.1016/j.cmet.2023.03.001. Epub 2023 Mar 23. Cell Metab. 2023. PMID: 36963395 Free PMC article.
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) i …
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositori …
Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis.
Ali RO, Quinn GM, Umarova R, Haddad JA, Zhang GY, Townsend EC, Scheuing L, Hill KL, Gewirtz M, Rampertaap S, Rosenzweig SD, Remaley AT, Han JM, Periwal V, Cai H, Walter PJ, Koh C, Levy EB, Kleiner DE, Etzion O, Heller T. Ali RO, et al. Nat Microbiol. 2023 Jan;8(1):12-27. doi: 10.1038/s41564-022-01273-y. Epub 2022 Dec 15. Nat Microbiol. 2023. PMID: 36522461
Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo.
Jo S, Pritchard S, Wong A, Avula N, Essawy A, Hanover J, Alejandro EU. Jo S, et al. Front Endocrinol (Lausanne). 2022 Oct 26;13:1040014. doi: 10.3389/fendo.2022.1040014. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36387851 Free PMC article.
Previous work showed that OGT is highly expressed in the pancreas, and we demonstrated that hypo-O-GlcNAcylation in beta-cells cause severe diabetes in mice. These studies show a direct link between nutrient-sensitive OGT and beta-cell health and function. ...
Previous work showed that OGT is highly expressed in the pancreas, and we demonstrated that hypo-O-GlcNAcylation in beta-cells cause severe …
Association between gestational diabetes and 6-year incident diabetes: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Casagrande SS, Avilés-Santa ML, Sotres-Alvarez D, Gallo L, Simon M, Kominiarek M, Talavera G, Stuebe AM, Potter J, Perera MJ, Isasi C, Gonzalez JS, Rust K, Cowie C. Casagrande SS, et al. BMJ Open Diabetes Res Care. 2022 Nov;10(6):e002980. doi: 10.1136/bmjdrc-2022-002980. BMJ Open Diabetes Res Care. 2022. PMID: 36375861 Free PMC article.
OBJECTIVE: Type 2 diabetes and gestational diabetes (GDM) disproportionately affect those of Hispanic/Latino heritage. ...Logistic regression was used to determine the association between GDM and prevalent (2008-2011) and incident (2014-2017) diabetes and int …
OBJECTIVE: Type 2 diabetes and gestational diabetes (GDM) disproportionately affect those of Hispanic/Latino heritage. ...Logi …
Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.
Jia D, Zhou Z, Kwon OJ, Zhang L, Wei X, Zhang Y, Yi M, Roudier MP, Regier MC, Dumpit R, Nelson PS, Headley M, True L, Lin DW, Morrissey C, Creighton CJ, Xin L. Jia D, et al. Nat Commun. 2022 Nov 11;13(1):6828. doi: 10.1038/s41467-022-34665-z. Nat Commun. 2022. PMID: 36369237 Free PMC article.
Augmenting lung stromal Foxf2 also mediates an immunosuppressive milieu and inhibits lung colonization of prostate cancer. FOXF2 is expressed higher in the stroma of human transition zone (TZ) than peripheral zone (PZ) prostate. The stromal FOXF2 expression level in primar …
Augmenting lung stromal Foxf2 also mediates an immunosuppressive milieu and inhibits lung colonization of prostate cancer. FOXF2 is expresse …
390 results