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T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.
Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A. Oseroff C, et al. J Immunol. 2012 Aug 15;189(4):1800-11. doi: 10.4049/jimmunol.1200850. Epub 2012 Jul 11. J Immunol. 2012. PMID: 22786768 Free PMC article.
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.
Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A. Moutaftsi M, et al. Future Microbiol. 2010 Feb;5(2):221-39. doi: 10.2217/fmb.09.110. Future Microbiol. 2010. PMID: 20143946 Free PMC article. Review.
Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice.
Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S, Crimi C, Vang L, Walker L, Ishioka G, Chitnis V, Sette A, Assarsson E, Hannaman D, Botten J, Newman MJ. Alexander J, et al. Vaccine. 2010 Jan 8;28(3):664-72. doi: 10.1016/j.vaccine.2009.10.103. Epub 2009 Nov 4. Vaccine. 2010. PMID: 19895924 Free PMC article.