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Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Jelínek M, Balušíková K, Daniel P, Němcová-Fürstová V, Kirubakaran P, Jaček M, Wei L, Wang X, Vondrášek J, Ojima I, Kovář J. Jelínek M, et al. Among authors: nemcova furstova v. Toxicol Appl Pharmacol. 2018 May 15;347:79-91. doi: 10.1016/j.taap.2018.04.002. Epub 2018 Apr 4. Toxicol Appl Pharmacol. 2018. PMID: 29625142 Free PMC article.
Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells.
Ehrlichová M, Ojima I, Chen J, Václavíková R, Němcová-Fürstová V, Vobořilová J, Simek P, Horský S, Souček P, Kovář J, Brabec M, Gut I. Ehrlichová M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1035-48. doi: 10.1007/s00210-012-0785-4. Epub 2012 Aug 2. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22855252
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