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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Weiss A, Lorthiois E, Barys L, Beyer KS, Bomio-Confaglia C, Burks H, Chen X, Cui X, de Kanter R, Dharmarajan L, Fedele C, Gerspacher M, Guthy DA, Head V, Jaeger A, Núñez EJ, Kearns JD, Leblanc C, Maira SM, Murphy J, Oakman H, Ostermann N, Ottl J, Rigollier P, Roman D, Schnell C, Sedrani R, Shimizu T, Stringer R, Vaupel A, Voshol H, Wessels P, Widmer T, Wilcken R, Xu K, Zecri F, Farago AF, Cotesta S, Brachmann SM. Weiss A, et al. Among authors: nunez ej. Cancer Discov. 2022 Jun 2;12(6):1500-1517. doi: 10.1158/2159-8290.CD-22-0158. Cancer Discov. 2022. PMID: 35404998 Free PMC article.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S, Hamon J, de Kanter R, Scheufler C, Andraos-Rey R, Barbe S, Bechter E, Blank J, Bordas V, Dammassa E, Decker A, Di Nanni N, Dourdoigne M, Gavioli E, Hattenberger M, Heuser A, Hemmerlin C, Hinrichs J, Kerr G, Laborde L, Jaco I, Núñez EJ, Martus HJ, Quadt C, Reschke M, Romanet V, Schaeffer F, Schoepfer J, Schrapp M, Strang R, Voshol H, Wartmann M, Welly S, Zécri F, Hofmann F, Möbitz H, Cortés-Cros M. Ferretti S, et al. Among authors: nunez ej. Nature. 2024 May;629(8011):443-449. doi: 10.1038/s41586-024-07350-y. Epub 2024 Apr 24. Nature. 2024. PMID: 38658754 Free PMC article.
Canines with different pathologies as carriers of diverse lineages of Escherichia coli harbouring mcr-1 and clinically relevant β-lactamases in central Ecuador.
Albán MV, Núñez EJ, Zurita J, Villacís JE, Tamayo R, Sevillano G, Villavicencio FX, Calero-Cáceres W. Albán MV, et al. Among authors: nunez ej. J Glob Antimicrob Resist. 2020 Sep;22:182-183. doi: 10.1016/j.jgar.2020.05.017. Epub 2020 Jun 6. J Glob Antimicrob Resist. 2020. PMID: 32522549 Free article. No abstract available.
[C-reactive protein].
Núñez EJ, Rivero I. Núñez EJ, et al. Medicina (B Aires). 1980 Jul-Aug;40(4):455-66. Medicina (B Aires). 1980. PMID: 7010069 Review. Spanish. No abstract available.