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Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
Vernekar SKV, Tang J, Wu B, Huber AD, Casey MC, Myshakina N, Wilson DJ, Kankanala J, Kirby KA, Parniak MA, Sarafianos SG, Wang Z. Vernekar SKV, et al. Among authors: myshakina n. J Med Chem. 2017 Jun 22;60(12):5045-5056. doi: 10.1021/acs.jmedchem.7b00440. Epub 2017 May 31. J Med Chem. 2017. PMID: 28525279 Free PMC article.
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
Kirby KA, Myshakina NA, Christen MT, Chen YL, Schmidt HA, Huber AD, Xi Z, Kim S, Rao RK, Kramer ST, Yang Q, Singh K, Parniak MA, Wang Z, Ishima R, Sarafianos SG. Kirby KA, et al. Among authors: myshakina na. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e01351-17. doi: 10.1128/AAC.01351-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28760905 Free PMC article.
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Tang J, Vernekar SKV, Chen YL, Miller L, Huber AD, Myshakina N, Sarafianos SG, Parniak MA, Wang Z. Tang J, et al. Among authors: myshakina n. Eur J Med Chem. 2017 Jun 16;133:85-96. doi: 10.1016/j.ejmech.2017.03.059. Epub 2017 Mar 29. Eur J Med Chem. 2017. PMID: 28384548 Free PMC article.
Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.
Xi Z, Wang Z, Sarafianos SG, Myshakina NS, Ishima R. Xi Z, et al. Among authors: myshakina ns. ACS Infect Dis. 2019 Nov 8;5(11):1963-1974. doi: 10.1021/acsinfecdis.9b00300. Epub 2019 Oct 2. ACS Infect Dis. 2019. PMID: 31577424 Free PMC article.
15 results