Myllyharju J - Search Results

1

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M. Deschoemaeker S, et al. Among authors: myllyharju j. EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492. EMBO Mol Med. 2015. PMID: 26290450 Free PMC article.

2

HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.

Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. Karsikas S, et al. Among authors: myllyharju j. J Mol Med (Berl). 2016 Mar;94(3):301-10. doi: 10.1007/s00109-015-1349-0. Epub 2015 Oct 10. J Mol Med (Berl). 2016. PMID: 26452676

3

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.

Ullah K, Rosendahl AH, Izzi V, Bergmann U, Pihlajaniemi T, Mäki JM, Myllyharju J. Ullah K, et al. Among authors: myllyharju j. Sci Rep. 2017 Dec 8;7(1):17220. doi: 10.1038/s41598-017-17376-0. Sci Rep. 2017. PMID: 29222481 Free PMC article.

4

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.

Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, Haapasaari KM, Myllyharju J, Serpi R, Dimova EY, Koivunen P. Laitakari A, et al. Among authors: myllyharju j. Redox Biol. 2019 Apr;22:101145. doi: 10.1016/j.redox.2019.101145. Epub 2019 Feb 19. Redox Biol. 2019. PMID: 30802717 Free PMC article.

5

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase.

Myllyharju J, Kivirikko KI. Myllyharju J, et al. EMBO J. 1997 Mar 17;16(6):1173-80. doi: 10.1093/emboj/16.6.1173. EMBO J. 1997. PMID: 9135134 Free PMC article.

6

Assembly of human prolyl 4-hydroxylase and type III collagen in the yeast pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl 4-hydroxylase.

Vuorela A, Myllyharju J, Nissi R, Pihlajaniemi T, Kivirikko KI. Vuorela A, et al. Among authors: myllyharju j. EMBO J. 1997 Nov 17;16(22):6702-12. doi: 10.1093/emboj/16.22.6702. EMBO J. 1997. PMID: 9362485 Free PMC article.

7

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase.

Myllyharju J, Kivirikko KI. Myllyharju J, et al. EMBO J. 1999 Jan 15;18(2):306-12. doi: 10.1093/emboj/18.2.306. EMBO J. 1999. PMID: 9889187 Free PMC article.

8

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J. Koivunen P, et al. Among authors: myllyharju j. J Biol Chem. 2004 Mar 12;279(11):9899-904. doi: 10.1074/jbc.M312254200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14701857 Free article.

9

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.

Myllyharju J. Myllyharju J. Ann Med. 2008;40(6):402-17. doi: 10.1080/07853890801986594. Ann Med. 2008. PMID: 19160570 Review.

10

HIF prolyl 4-hydroxylases and their potential as drug targets.

Myllyharju J. Myllyharju J. Curr Pharm Des. 2009;15(33):3878-85. doi: 10.2174/138161209789649457. Curr Pharm Des. 2009. PMID: 19671043 Review.

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