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Photoswitchable Probes of Oxytocin and Vasopressin.
Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M, König B. Wirth U, et al. Among authors: muttenthaler m. J Med Chem. 2023 Nov 9;66(21):14853-14865. doi: 10.1021/acs.jmedchem.3c01415. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857356 Free PMC article.
Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B. Busnelli M, et al. Among authors: muttenthaler m. J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28. J Med Chem. 2016. PMID: 27420737 Free article.
Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.
Peschel A, Cardoso FC, Walker AA, Durek T, Stone MRL, Braga Emidio N, Dawson PE, Muttenthaler M, King GF. Peschel A, et al. Among authors: muttenthaler m. J Med Chem. 2020 Nov 12;63(21):12773-12785. doi: 10.1021/acs.jmedchem.0c01107. Epub 2020 Oct 20. J Med Chem. 2020. PMID: 33078946 Free PMC article.
Improving the Gastrointestinal Stability of Linaclotide.
Braga Emidio N, Tran HNT, Andersson A, Dawson PE, Albericio F, Vetter I, Muttenthaler M. Braga Emidio N, et al. Among authors: muttenthaler m. J Med Chem. 2021 Jun 24;64(12):8384-8390. doi: 10.1021/acs.jmedchem.1c00380. Epub 2021 May 12. J Med Chem. 2021. PMID: 33979161 Free PMC article.
On the Utility of Chemical Strategies to Improve Peptide Gut Stability.
Kremsmayr T, Aljnabi A, Blanco-Canosa JB, Tran HNT, Emidio NB, Muttenthaler M. Kremsmayr T, et al. Among authors: muttenthaler m. J Med Chem. 2022 Apr 28;65(8):6191-6206. doi: 10.1021/acs.jmedchem.2c00094. Epub 2022 Apr 14. J Med Chem. 2022. PMID: 35420805 Free PMC article.
Oxytocin and vasopressin signaling in health and disease.
Perisic M, Woolcock K, Hering A, Mendel H, Muttenthaler M. Perisic M, et al. Among authors: muttenthaler m. Trends Biochem Sci. 2024 Apr;49(4):361-377. doi: 10.1016/j.tibs.2024.01.010. Epub 2024 Feb 27. Trends Biochem Sci. 2024. PMID: 38418338 Review.
54 results