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Therapeutic potential of chemically modified siRNA: Recent trends.
Chem Biol Drug Des. 2017 Nov;90(5):665-678. doi: 10.1111/cbdd.12993. Epub 2017 May 16.
Chem Biol Drug Des. 2017.
PMID: 28378934
Free PMC article.
Review.
Pterocarpan scaffold: A natural lead molecule with diverse pharmacological properties.
Selvam C, Jordan BC, Prakash S, Mutisya D, Thilagavathi R.
Selvam C, et al. Among authors: mutisya d.
Eur J Med Chem. 2017 Mar 10;128:219-236. doi: 10.1016/j.ejmech.2017.01.023. Epub 2017 Jan 17.
Eur J Med Chem. 2017.
PMID: 28189086
Review.
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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Mutisya D, Selvam C, Lunstad BD, Pallan PS, Haas A, Leake D, Egli M, Rozners E.
Mutisya D, et al.
Nucleic Acids Res. 2014 Jun;42(10):6542-51. doi: 10.1093/nar/gku235. Epub 2014 May 9.
Nucleic Acids Res. 2014.
PMID: 24813446
Free PMC article.
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Synthesis and properties of triazole-linked RNA.
Mutisya D, Selvam C, Kennedy SD, Rozners E.
Mutisya D, et al.
Bioorg Med Chem Lett. 2011 Jun 1;21(11):3420-2. doi: 10.1016/j.bmcl.2011.03.111. Epub 2011 Apr 5.
Bioorg Med Chem Lett. 2011.
PMID: 21524577
Free PMC article.
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Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Mutisya D, Hardcastle T, Cheruiyot SK, Pallan PS, Kennedy SD, Egli M, Kelley ML, Smith AVB, Rozners E.
Mutisya D, et al.
Nucleic Acids Res. 2017 Aug 21;45(14):8142-8155. doi: 10.1093/nar/gkx558.
Nucleic Acids Res. 2017.
PMID: 28854734
Free PMC article.
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A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs.
Hardcastle T, Novosjolova I, Kotikam V, Cheruiyot SK, Mutisya D, Kennedy SD, Egli M, Kelley ML, Smith AVB, Rozners E.
Hardcastle T, et al. Among authors: mutisya d.
ACS Chem Biol. 2018 Mar 16;13(3):533-536. doi: 10.1021/acschembio.7b01012. Epub 2018 Jan 10.
ACS Chem Biol. 2018.
PMID: 29298376
Free PMC article.
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A novel siRNA-gemcitabine construct as a potential therapeutic for treatment of pancreatic cancer.
Simonenko V, Lu X, Roesch E, Mutisya D, Shao C, Sun Q, Patterson-Orazem A, McNair M, Shanmuganathan A, Lu P, Evans DM.
Simonenko V, et al. Among authors: mutisya d.
NAR Cancer. 2020 Aug 11;2(3):zcaa016. doi: 10.1093/narcan/zcaa016. eCollection 2020 Sep.
NAR Cancer. 2020.
PMID: 34316688
Free PMC article.
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