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Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.
Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Rahaman MM, et al. Among authors: mutchler sm. J Biol Chem. 2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. Epub 2015 May 22. J Biol Chem. 2015. PMID: 26001785 Free PMC article.
Intercalated cell BKα subunit is required for flow-induced K+ secretion.
Carrisoza-Gaytan R, Ray EC, Flores D, Marciszyn AL, Wu P, Liu L, Subramanya AR, Wang W, Sheng S, Nkashama LJ, Chen J, Jackson EK, Mutchler SM, Heja S, Kohan DE, Satlin LM, Kleyman TR. Carrisoza-Gaytan R, et al. Among authors: mutchler sm. JCI Insight. 2020 Apr 7;5(8):e130553. doi: 10.1172/jci.insight.130553. JCI Insight. 2020. PMID: 32255763 Free PMC article.
Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice.
Wang XP, Mutchler SM, Carrisoza-Gáytan R, Al-Bataineh M, Baty CJ, Vandevender A, Srinivasan P, Tan RJ, Jurczak MJ, Satlin LM, Kashlan OB. Wang XP, et al. Among authors: mutchler sm. bioRxiv [Preprint]. 2023 Sep 22:2023.09.19.558474. doi: 10.1101/2023.09.19.558474. bioRxiv. 2023. PMID: 37790468 Free PMC article. Preprint.
Effects of extreme potassium stress on blood pressure and renal tubular sodium transport.
Boyd-Shiwarski CR, Weaver CJ, Beacham RT, Shiwarski DJ, Connolly KA, Nkashama LJ, Mutchler SM, Griffiths SE, Knoell SA, Sebastiani RS, Ray EC, Marciszyn AL, Subramanya AR. Boyd-Shiwarski CR, et al. Among authors: mutchler sm. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1341-F1356. doi: 10.1152/ajprenal.00527.2019. Epub 2020 Apr 13. Am J Physiol Renal Physiol. 2020. PMID: 32281415 Free PMC article.
The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
Porter AW, Nguyen DN, Clayton DR, Ruiz WG, Mutchler SM, Ray EC, Marciszyn AL, Nkashama LJ, Subramanya AR, Gingras S, Kleyman TR, Apodaca G, Hendershot LM, Brodsky JL, Buck TM. Porter AW, et al. Among authors: mutchler sm. JCI Insight. 2022 Mar 8;7(5):e151869. doi: 10.1172/jci.insight.151869. JCI Insight. 2022. PMID: 35104250 Free PMC article.
27 results