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In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity.
D'Antona L, Dattilo V, Catalogna G, Scumaci D, Fiumara CV, Musumeci F, Perrotti G, Schenone S, Tallerico R, Spoleti CB, Costa N, Iuliano R, Cuda G, Amato R, Perrotti N. D'Antona L, et al. Among authors: musumeci f. Transl Oncol. 2019 Aug;12(8):1045-1055. doi: 10.1016/j.tranon.2019.05.008. Epub 2019 Jun 1. Transl Oncol. 2019. PMID: 31163384 Free PMC article.
An update on dual Src/Abl inhibitors.
Musumeci F, Schenone S, Brullo C, Botta M. Musumeci F, et al. Future Med Chem. 2012 Apr;4(6):799-822. doi: 10.4155/fmc.12.29. Future Med Chem. 2012. PMID: 22530642 Review.
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold.
Ortuso F, Amato R, Artese A, D'antona L, Costa G, Talarico C, Gigliotti F, Bianco C, Trapasso F, Schenone S, Musumeci F, Botta L, Perrotti N, Alcaro S. Ortuso F, et al. Among authors: musumeci f. J Chem Inf Model. 2014 Jul 28;54(7):1828-32. doi: 10.1021/ci500235f. Epub 2014 Jun 13. J Chem Inf Model. 2014. PMID: 24896223
Bcr-Abl tyrosine kinase inhibitors: a patent review.
Desogus A, Schenone S, Brullo C, Tintori C, Musumeci F. Desogus A, et al. Among authors: musumeci f. Expert Opin Ther Pat. 2015 Apr;25(4):397-412. doi: 10.1517/13543776.2015.1012155. Epub 2015 Feb 6. Expert Opin Ther Pat. 2015. PMID: 25656651 Review.
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N. D'Antona L, et al. Among authors: musumeci f. Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27. Cell Physiol Biochem. 2015. PMID: 25871776 Free article.
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.
Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: musumeci f. Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520. Oncotarget. 2016. PMID: 26908461 Free PMC article.
361 results