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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Wang S, et al. Among authors: musselman ca. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31755685 Free PMC article.
Inhibition of histone binding by supramolecular hosts.
Allen HF, Daze KD, Shimbo T, Lai A, Musselman CA, Sims JK, Wade PA, Hof F, Kutateladze TG. Allen HF, et al. Among authors: musselman ca. Biochem J. 2014 May 1;459(3):505-12. doi: 10.1042/BJ20140145. Biochem J. 2014. PMID: 24576085 Free PMC article.
Covalent Modifications of Histone H3K9 Promote Binding of CHD3.
Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X, Sims JK, Weaver TM, Allen HF, Zhang Y, Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W, Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG. Tencer AH, et al. Among authors: musselman ca. Cell Rep. 2017 Oct 10;21(2):455-466. doi: 10.1016/j.celrep.2017.09.054. Cell Rep. 2017. PMID: 29020631 Free PMC article.
Reprogramming CBX8-PRC1 function with a positive allosteric modulator.
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Suh JL, et al. Among authors: musselman ca. Cell Chem Biol. 2022 Apr 21;29(4):555-571.e11. doi: 10.1016/j.chembiol.2021.10.003. Epub 2021 Oct 28. Cell Chem Biol. 2022. PMID: 34715055 Free PMC article.
PBRM1 bromodomains associate with RNA to facilitate chromatin association.
De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, Vögeli B, Dykhuizen EC, Musselman CA. De Silva SM, et al. Among authors: musselman ca. Nucleic Acids Res. 2023 May 8;51(8):3631-3649. doi: 10.1093/nar/gkad072. Nucleic Acids Res. 2023. PMID: 36808431 Free PMC article.
56 results