Musielak B - Search Results

1

Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction.

Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA. Kitel R, et al. Among authors: musielak b. J Med Chem. 2023 Dec 14;66(23):15715-15727. doi: 10.1021/acs.jmedchem.3c00877. Epub 2023 Dec 1. J Med Chem. 2023. PMID: 38039505 Free PMC article.

2

Conformations and Conformational Processes of Hexahydrobenzazocines by NMR and DFT Studies.

Musielak B, Holak TA, Rys B. Musielak B, et al. J Org Chem. 2015 Sep 18;80(18):9231-9. doi: 10.1021/acs.joc.5b01687. Epub 2015 Sep 3. J Org Chem. 2015. PMID: 26317238

3

Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.

Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Dömling A, Dubin G, Holak TA. Zak KM, et al. Among authors: musielak b. Structure. 2015 Dec 1;23(12):2341-2348. doi: 10.1016/j.str.2015.09.010. Epub 2015 Oct 22. Structure. 2015. PMID: 26602187 Free PMC article.

4

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).

Zak KM, Grudnik P, Guzik K, Zieba BJ, Musielak B, Dömling A, Dubin G, Holak TA. Zak KM, et al. Among authors: musielak b. Oncotarget. 2016 May 24;7(21):30323-35. doi: 10.18632/oncotarget.8730. Oncotarget. 2016. PMID: 27083005 Free PMC article.

5

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.

Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA. Surmiak E, et al. Among authors: musielak b. ACS Chem Biol. 2016 Dec 16;11(12):3310-3318. doi: 10.1021/acschembio.6b00596. Epub 2016 Oct 17. ACS Chem Biol. 2016. PMID: 27709883

6

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A. Surmiak E, et al. Among authors: musielak b. Eur J Med Chem. 2017 Jan 27;126:384-407. doi: 10.1016/j.ejmech.2016.11.029. Epub 2016 Nov 16. Eur J Med Chem. 2017. PMID: 27907876

7

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.

Guzik K, Zak KM, Grudnik P, Magiera K, Musielak B, Törner R, Skalniak L, Dömling A, Dubin G, Holak TA. Guzik K, et al. Among authors: musielak b. J Med Chem. 2017 Jul 13;60(13):5857-5867. doi: 10.1021/acs.jmedchem.7b00293. Epub 2017 Jun 23. J Med Chem. 2017. PMID: 28613862

8

Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.

Madhavachary R, Abdelraheem EMM, Rossetti A, Twarda-Clapa A, Musielak B, Kurpiewska K, Kalinowska-Tłuścik J, Holak TA, Dömling A. Madhavachary R, et al. Among authors: musielak b. Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10725-10729. doi: 10.1002/anie.201704426. Epub 2017 Aug 1. Angew Chem Int Ed Engl. 2017. PMID: 28691783 Free PMC article.

9

Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.

Magiera-Mularz K, Skalniak L, Zak KM, Musielak B, Rudzinska-Szostak E, Berlicki Ł, Kocik J, Grudnik P, Sala D, Zarganes-Tzitzikas T, Shaabani S, Dömling A, Dubin G, Holak TA. Magiera-Mularz K, et al. Among authors: musielak b. Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13732-13735. doi: 10.1002/anie.201707707. Epub 2017 Sep 26. Angew Chem Int Ed Engl. 2017. PMID: 28881104 Free PMC article.

10

Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists^†.

Shaabani S, Neochoritis CG, Twarda-Clapa A, Musielak B, Holak TA, Dömling A. Shaabani S, et al. Among authors: musielak b. Medchemcomm. 2017 May 1;8(5):1046-1052. doi: 10.1039/C7MD00058H. Epub 2017 Mar 15. Medchemcomm. 2017. PMID: 29034069 Free PMC article.

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