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TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B. Arseni D, et al. Among authors: murzin ag. Nature. 2023 Aug;620(7975):898-903. doi: 10.1038/s41586-023-06405-w. Epub 2023 Aug 2. Nature. 2023. PMID: 37532939 Free PMC article.
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lövestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW. Yang Y, et al. Among authors: murzin ag. Acta Neuropathol. 2023 Mar;145(3):325-333. doi: 10.1007/s00401-022-02533-1. Epub 2023 Jan 7. Acta Neuropathol. 2023. PMID: 36611124 Free PMC article.
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy.
Yang Y, Garringer HJ, Shi Y, Lövestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M. Yang Y, et al. Among authors: murzin ag. Acta Neuropathol. 2023 May;145(5):561-572. doi: 10.1007/s00401-023-02550-8. Epub 2023 Feb 27. Acta Neuropathol. 2023. PMID: 36847833 Free PMC article.
Disease-specific tau filaments assemble via polymorphic intermediates.
Lövestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW. Lövestam S, et al. Among authors: murzin ag. Nature. 2024 Jan;625(7993):119-125. doi: 10.1038/s41586-023-06788-w. Epub 2023 Nov 29. Nature. 2024. PMID: 38030728 Free PMC article.
TAF15 amyloid filaments in frontotemporal lobar degeneration.
Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B. Tetter S, et al. Among authors: murzin ag. Nature. 2024 Jan;625(7994):345-351. doi: 10.1038/s41586-023-06801-2. Epub 2023 Dec 6. Nature. 2024. PMID: 38057661 Free PMC article.
Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Qi C, et al. Among authors: murzin ag. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2306767120. doi: 10.1073/pnas.2306767120. Epub 2023 Dec 15. Proc Natl Acad Sci U S A. 2023. PMID: 38100415 Free PMC article.
Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W.
Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M. Qi C, et al. Among authors: murzin ag. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591661. doi: 10.1101/2024.04.29.591661. bioRxiv. 2024. PMID: 38746388 Free PMC article. Preprint.
Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold.
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Qi C, et al. Among authors: murzin ag. bioRxiv [Preprint]. 2023 Apr 28:2023.04.26.538417. doi: 10.1101/2023.04.26.538417. bioRxiv. 2023. PMID: 37162924 Free PMC article. Updated. Preprint.
108 results