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Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines.
Tregoning JS, Stirling DC, Wang Z, Flight KE, Brown JC, Blakney AK, McKay PF, Cunliffe RF, Murugaiah V, Fox CB, Beattie M, Tam YK, Johansson C, Shattock RJ. Tregoning JS, et al. Among authors: murugaiah v. Mol Ther Nucleic Acids. 2022 Dec 5;31:29-42. doi: 10.1016/j.omtn.2022.11.024. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2022. PMID: 36589712 Free PMC article.
A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague.
Shattock RJ, Andrianaivoarimanana V, McKay PF, Randriantseheno LN, Murugaiah V, Samnuan K, Rogers P, Tregoning JS, Rajerison M, Moore KM, Laws TR, Williamson ED. Shattock RJ, et al. Among authors: murugaiah v. Front Microbiol. 2023 Nov 2;14:1247041. doi: 10.3389/fmicb.2023.1247041. eCollection 2023. Front Microbiol. 2023. PMID: 38029221 Free PMC article.
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons.
Zhang Y, Zhang LS, Dai Q, Chen P, Lu M, Kairis EL, Murugaiah V, Xu J, Shukla RK, Liang X, Zou Z, Cormet-Boyaka E, Qiu J, Peeples ME, Sharma A, He C, Li J. Zhang Y, et al. Among authors: murugaiah v. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2123338119. doi: 10.1073/pnas.2123338119. Epub 2022 Oct 14. Proc Natl Acad Sci U S A. 2022. PMID: 36240321 Free PMC article.
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation.
Beirag N, Kumar C, Madan T, Shamji MH, Bulla R, Mitchell D, Murugaiah V, Neto MM, Temperton N, Idicula-Thomas S, Varghese PM, Kishore U. Beirag N, et al. Among authors: murugaiah v. Front Immunol. 2022 Jul 28;13:960733. doi: 10.3389/fimmu.2022.960733. eCollection 2022. Front Immunol. 2022. PMID: 35967323 Free PMC article.
Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection.
Varghese PM, Mukherjee S, Al-Mohanna FA, Saleh SM, Almajhdi FN, Beirag N, Alkahtani SH, Rajkumari R, Nal Rogier B, Sim RB, Idicula-Thomas S, Madan T, Murugaiah V, Kishore U. Varghese PM, et al. Among authors: murugaiah v. Front Immunol. 2021 Dec 9;12:747654. doi: 10.3389/fimmu.2021.747654. eCollection 2021. Front Immunol. 2021. PMID: 34956182 Free PMC article.
Innate Immune Response Against HIV-1.
Murugaiah V, Yasmin H, Pandit H, Ganguly K, Subedi R, Al-Mozaini M, Madan T, Kishore U. Murugaiah V, et al. Adv Exp Med Biol. 2021;1313:23-58. doi: 10.1007/978-3-030-67452-6_3. Adv Exp Med Biol. 2021. PMID: 34661890
30 results