Murray KA - Search Results

1

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.

Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Dickson DW, Vinters HV, Eisenberg DS. Seidler PM, et al. Among authors: murray ka. Nat Commun. 2022 Sep 16;13(1):5451. doi: 10.1038/s41467-022-32951-4. Nat Commun. 2022. PMID: 36114178 Free PMC article.

2

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.

Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Krotee P, et al. J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27. J Biol Chem. 2018. PMID: 29282295 Free PMC article.

3

Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. Seidler PM, et al. Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20. Nat Chem. 2018. PMID: 29359764 Free PMC article.

4

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.

Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS. Sangwan S, et al. Among authors: murray ka. Protein Sci. 2018 Jul;27(7):1231-1242. doi: 10.1002/pro.3391. Epub 2018 Mar 10. Protein Sci. 2018. PMID: 29453800 Free PMC article.

5

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.

Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Li B, et al. Among authors: murray ka. Nat Commun. 2018 Sep 6;9(1):3609. doi: 10.1038/s41467-018-05971-2. Nat Commun. 2018. PMID: 30190461 Free PMC article.

6

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Cao Q, et al. Among authors: murray ka. Nat Chem. 2018 Dec;10(12):1213-1221. doi: 10.1038/s41557-018-0147-z. Epub 2018 Oct 8. Nat Chem. 2018. PMID: 30297750 Free PMC article.

7

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. Cao Q, et al. Among authors: murray ka. Nat Chem. 2018 Dec;10(12):1267. doi: 10.1038/s41557-018-0182-9. Nat Chem. 2018. PMID: 30420778 Free PMC article.

8

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.

Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. Seidler PM, et al. Among authors: murray ka. J Biol Chem. 2019 Nov 1;294(44):16451-16464. doi: 10.1074/jbc.RA119.009688. Epub 2019 Sep 19. J Biol Chem. 2019. PMID: 31537646 Free PMC article.

9

Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Griner SL, et al. Among authors: murray ka. Elife. 2019 Oct 15;8:e46924. doi: 10.7554/eLife.46924. Elife. 2019. PMID: 31612856 Free PMC article.

10

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation.

Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Shin WS, et al. Among authors: murray ka. Alzheimers Res Ther. 2019 Oct 18;11(1):86. doi: 10.1186/s13195-019-0541-9. Alzheimers Res Ther. 2019. PMID: 31627745 Free PMC article.

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