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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.
Nucleic Acids Res. 2014 Jul;42(13):8796-807. doi: 10.1093/nar/gku531. Epub 2014 Jul 3.
Nucleic Acids Res. 2014.
PMID: 24992960
Free PMC article.
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.
Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST.
Lima WF, et al.
J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18.
J Biol Chem. 2009.
PMID: 19017633
Free article.
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Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
Schirle NT, Kinberger GA, Murray HF, Lima WF, Prakash TP, MacRae IJ.
Schirle NT, et al. Among authors: murray hf.
J Am Chem Soc. 2016 Jul 20;138(28):8694-7. doi: 10.1021/jacs.6b04454. Epub 2016 Jul 12.
J Am Chem Soc. 2016.
PMID: 27380263
Free PMC article.
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