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Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver.
Franke-Fayard B, Marin-Mogollon C, Geurten FJA, Chevalley-Maurel S, Ramesar J, Kroeze H, Baalbergen E, Wessels E, Baron L, Soulard V, Martinson T, Aleshnick M, Huijs ATG, Subudhi AK, Miyazaki Y, Othman AS, Kolli SK, Lamers OAC, Roques M, Stanway RR, Murphy SC, Foquet L, Moita D, Mendes AM, Prudêncio M, Dechering KJ, Heussler VT, Pain A, Wilder BK, Roestenberg M, Janse CJ. Franke-Fayard B, et al. Among authors: murphy sc. NPJ Vaccines. 2022 Nov 4;7(1):139. doi: 10.1038/s41541-022-00558-x. NPJ Vaccines. 2022. PMID: 36333336 Free PMC article.
Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.
Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI. Sack BK, et al. Among authors: murphy sc. NPJ Vaccines. 2017 Oct 9;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017. NPJ Vaccines. 2017. PMID: 29263882 Free PMC article.
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.
Flannery EL, Foquet L, Chuenchob V, Fishbaugher M, Billman Z, Navarro MJ, Betz W, Olsen TM, Lee J, Camargo N, Nguyen T, Schafer C, Sack BK, Wilson EM, Saunders J, Bial J, Campo B, Charman SA, Murphy SC, Phillips MA, Kappe SH, Mikolajczak SA. Flannery EL, et al. Among authors: murphy sc. JCI Insight. 2018 Jan 11;3(1):e92587. doi: 10.1172/jci.insight.92587. eCollection 2018 Jan 11. JCI Insight. 2018. PMID: 29321371 Free PMC article.
Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo.
Foquet L, Schafer C, Minkah NK, Alanine DGW, Flannery EL, Steel RWJ, Sack BK, Camargo N, Fishbaugher M, Betz W, Nguyen T, Billman ZP, Wilson EM, Bial J, Murphy SC, Draper SJ, Mikolajczak SA, Kappe SHI. Foquet L, et al. Among authors: murphy sc. Front Immunol. 2018 Mar 14;9:524. doi: 10.3389/fimmu.2018.00524. eCollection 2018. Front Immunol. 2018. PMID: 29593746 Free PMC article.
A replication-competent late liver stage-attenuated human malaria parasite.
Goswami D, Betz W, Locham NK, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Kennedy SY, Murphy SC, Vaughan AM, Kappe SH. Goswami D, et al. Among authors: murphy sc. JCI Insight. 2020 Jul 9;5(13):e135589. doi: 10.1172/jci.insight.135589. JCI Insight. 2020. PMID: 32484795 Free PMC article.
Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies.
Wilder BK, Vigdorovich V, Carbonetti S, Minkah N, Hertoghs N, Raappana A, Cardamone H, Oliver BG, Trakhimets O, Kumar S, Dambrauskas N, Arredondo SA, Camargo N, Seilie AM, Murphy SC, Kappe SHI, Sather DN. Wilder BK, et al. Among authors: murphy sc. NPJ Vaccines. 2022 May 26;7(1):58. doi: 10.1038/s41541-022-00480-2. NPJ Vaccines. 2022. PMID: 35618791 Free PMC article.
Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine.
Flannery EL, Kangwanrangsan N, Chuenchob V, Roobsoong W, Fishbaugher M, Zhou K, Billman ZP, Martinson T, Olsen TM, Schäfer C, Campo B, Murphy SC, Mikolajczak SA, Kappe SHI, Sattabongkot J. Flannery EL, et al. Among authors: murphy sc. Mol Ther Methods Clin Dev. 2022 Aug 2;26:427-440. doi: 10.1016/j.omtm.2022.07.016. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36092359 Free PMC article.
Needle-free, spirulina-produced Plasmodium falciparum circumsporozoite vaccination provides sterile protection against pre-erythrocytic malaria in mice.
Saveria T, Parthiban C, Seilie AM, Brady C, Martinez A, Manocha R, Afreen E, Zhao H, Krzeszowski A, Ferrara J, Paddock T, Roberts J, Stone BC, Tasch M, Murphy SC. Saveria T, et al. Among authors: murphy sc. NPJ Vaccines. 2022 Oct 4;7(1):113. doi: 10.1038/s41541-022-00534-5. NPJ Vaccines. 2022. PMID: 36195607 Free PMC article.
Sporozoite immunization: innovative translational science to support the fight against malaria.
Richie TL, Church LWP, Murshedkar T, Billingsley PF, James ER, Chen MC, Abebe Y, Natasha Kc, Chakravarty S, Dolberg D, Healy SA, Diawara H, Sissoko MS, Sagara I, Cook DM, Epstein JE, Mordmüller B, Kapulu M, Kreidenweiss A, Franke-Fayard B, Agnandji ST, López Mikue MA, McCall MBB, Steinhardt L, Oneko M, Olotu A, Vaughan AM, Kublin JG, Murphy SC, Jongo S, Tanner M, Sirima SB, Laurens MB, Daubenberger C, Silva JC, Lyke KE, Janse CJ, Roestenberg M, Sauerwein RW, Abdulla S, Dicko A, Kappe SHI, Sim BKL, Duffy PE, Kremsner PG, Hoffman SL. Richie TL, et al. Among authors: murphy sc. Expert Rev Vaccines. 2023 Jan-Dec;22(1):964-1007. doi: 10.1080/14760584.2023.2245890. Epub 2023 Aug 11. Expert Rev Vaccines. 2023. PMID: 37571809 Free PMC article. Review.
157 results