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Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.
Lu Z, Van Eeckhoutte HP, Liu G, Nair PM, Jones B, Gillis CM, Nalkurthi BC, Verhamme F, Buyle-Huybrecht T, Vandenabeele P, Vanden Berghe T, Brusselle GG, Horvat JC, Murphy JM, Wark PA, Bracke KR, Fricker M, Hansbro PM. Lu Z, et al. Among authors: murphy jm. Am J Respir Crit Care Med. 2021 Sep 15;204(6):667-681. doi: 10.1164/rccm.202009-3442OC. Am J Respir Crit Care Med. 2021. PMID: 34133911
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.
Necroptosis induced by RIPK3 requires MLKL but not Drp1.
Moujalled DM, Cook WD, Murphy JM, Vaux DL. Moujalled DM, et al. Among authors: murphy jm. Cell Death Dis. 2014 Feb 27;5(2):e1086. doi: 10.1038/cddis.2014.18. Cell Death Dis. 2014. PMID: 24577084 Free PMC article.
Evolutionary divergence of the necroptosis effector MLKL.
Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Tanzer MC, et al. Among authors: murphy jm. Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868910 Free PMC article.
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.
Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S. Günther C, et al. Among authors: murphy jm. J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17. J Clin Invest. 2016. PMID: 27756058 Free PMC article.
776 results