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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.
Necroptosis induced by RIPK3 requires MLKL but not Drp1.
Moujalled DM, Cook WD, Murphy JM, Vaux DL. Moujalled DM, et al. Among authors: murphy jm. Cell Death Dis. 2014 Feb 27;5(2):e1086. doi: 10.1038/cddis.2014.18. Cell Death Dis. 2014. PMID: 24577084 Free PMC article.
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J. Rickard JA, et al. Among authors: murphy jm. Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8. Cell. 2014. PMID: 24813849 Free article.
The molecular regulation of Janus kinase (JAK) activation.
Babon JJ, Lucet IS, Murphy JM, Nicola NA, Varghese LN. Babon JJ, et al. Among authors: murphy jm. Biochem J. 2014 Aug 15;462(1):1-13. doi: 10.1042/BJ20140712. Biochem J. 2014. PMID: 25057888 Free PMC article. Review.
780 results