Murelli RP - Search Results

1

Broad anti-herpesviral activity of α-hydroxytropolones.

Dehghanpir SD, Birkenheuer CH, Yang K, Murelli RP, Morrison LA, Le Grice SFJ, Baines JD. Dehghanpir SD, et al. Among authors: murelli rp. Vet Microbiol. 2018 Feb;214:125-131. doi: 10.1016/j.vetmic.2017.12.016. Epub 2017 Dec 27. Vet Microbiol. 2018. PMID: 29408023 Free PMC article.

2

An oxidopyrylium cyclization/ring-opening route to polysubstituted α-hydroxytropolones.

Meck C, Mohd N, Murelli RP. Meck C, et al. Among authors: murelli rp. Org Lett. 2012 Dec 7;14(23):5988-91. doi: 10.1021/ol302892g. Epub 2012 Nov 20. Org Lett. 2012. PMID: 23167954 Free PMC article.

3

Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones.

Hirsch DR, Cox G, D'Erasmo MP, Shakya T, Meck C, Mohd N, Wright GD, Murelli RP. Hirsch DR, et al. Among authors: murelli rp. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4943-7. doi: 10.1016/j.bmcl.2014.09.037. Epub 2014 Sep 19. Bioorg Med Chem Lett. 2014. PMID: 25283553 Free PMC article.

4

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.

Lu G, Lomonosova E, Cheng X, Moran EA, Meyers MJ, Le Grice SF, Thomas CJ, Jiang JK, Meck C, Hirsch DR, D'Erasmo MP, Suyabatmaz DM, Murelli RP, Tavis JE. Lu G, et al. Among authors: murelli rp. Antimicrob Agents Chemother. 2015 Feb;59(2):1070-9. doi: 10.1128/AAC.04617-14. Epub 2014 Dec 1. Antimicrob Agents Chemother. 2015. PMID: 25451058 Free PMC article.

5

Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.

Zhao H, Lin Z, Lynn AY, Varnado B, Beutler JA, Murelli RP, Le Grice SF, Tang L. Zhao H, et al. Among authors: murelli rp. Nucleic Acids Res. 2015 Dec 15;43(22):11003-16. doi: 10.1093/nar/gkv1018. Epub 2015 Oct 7. Nucleic Acids Res. 2015. PMID: 26450964 Free PMC article.

6

Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.

Ireland PJ, Tavis JE, D'Erasmo MP, Hirsch DR, Murelli RP, Cadiz MM, Patel BS, Gupta AK, Edwards TC, Korom M, Moran EA, Morrison LA. Ireland PJ, et al. Among authors: murelli rp. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2140-9. doi: 10.1128/AAC.02675-15. Print 2016 Apr. Antimicrob Agents Chemother. 2016. PMID: 26787704 Free PMC article.

7

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors.

Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Varnado B, Gupta A, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SF. Masaoka T, et al. Among authors: murelli rp. Biochemistry. 2016 Feb 9;55(5):809-19. doi: 10.1021/acs.biochem.5b01254. Epub 2016 Feb 1. Biochemistry. 2016. PMID: 26829613 Free PMC article.

8

Traceless Solid-Phase α-Hydroxytropolone Synthesis.

D'Erasmo MP, Masaoka T, Wilson JA, Hunte EM Jr, Beutler JA, Le Grice SF, Murelli RP. D'Erasmo MP, et al. Among authors: murelli rp. Medchemcomm. 2016 Sep 1;7(9):1789-1792. doi: 10.1039/C6MD00237D. Epub 2016 Jul 7. Medchemcomm. 2016. PMID: 28090282 Free PMC article.

9

Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.

Murelli RP, D'Erasmo MP, Hirsch DR, Meck C, Masaoka T, Wilson JA, Zhang B, Pal RK, Gallicchio E, Beutler JA, Le Grice SF. Murelli RP, et al. Medchemcomm. 2016 Sep 1;7(9):1783-1788. doi: 10.1039/C6MD00238B. Epub 2016 Jul 7. Medchemcomm. 2016. PMID: 28093576 Free PMC article.

10

Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H.

Lomonosova E, Daw J, Garimallaprabhakaran AK, Agyemang NB, Ashani Y, Murelli RP, Tavis JE. Lomonosova E, et al. Among authors: murelli rp. Antiviral Res. 2017 Aug;144:164-172. doi: 10.1016/j.antiviral.2017.06.014. Epub 2017 Jun 17. Antiviral Res. 2017. PMID: 28633989 Free PMC article.

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