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Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.
Shen Y, Muramatsu SI, Ikeguchi K, Fujimoto KI, Fan DS, Ogawa M, Mizukami H, Urabe M, Kume A, Nagatsu I, Urano F, Suzuki T, Ichinose H, Nagatsu T, Monahan J, Nakano I, Ozawa K. Shen Y, et al. Among authors: muramatsu si. Hum Gene Ther. 2000 Jul 20;11(11):1509-19. doi: 10.1089/10430340050083243. Hum Gene Ther. 2000. PMID: 10945765
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K. Muramatsu S, et al. Hum Gene Ther. 2002 Feb 10;13(3):345-54. doi: 10.1089/10430340252792486. Hum Gene Ther. 2002. PMID: 11860702
Gene therapy for aromatic L-amino acid decarboxylase deficiency.
Hwu WL, Muramatsu S, Tseng SH, Tzen KY, Lee NC, Chien YH, Snyder RO, Byrne BJ, Tai CH, Wu RM. Hwu WL, et al. Sci Transl Med. 2012 May 16;4(134):134ra61. doi: 10.1126/scitranslmed.3003640. Sci Transl Med. 2012. PMID: 22593174 Clinical Trial.
310 results