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Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling.
Huang C, Sharma A, Thakur R, Rai D, Katiki M, Germano JF, Song Y, Singh S, Sin J, Sengstock D, Andres AM, Murali R, Mentzer RM Jr, Gottlieb RA, Piplani H. Huang C, et al. Among authors: murali r. Matrix Biol. 2022 Jun;110:40-59. doi: 10.1016/j.matbio.2022.04.005. Epub 2022 Apr 22. Matrix Biol. 2022. PMID: 35470068 Free PMC article.
Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress.
Thomas TM, Miyaguchi K, Edwards LA, Wang H, Wollebo H, Aiguo L, Murali R, Wang Y, Braas D, Michael JS, Andres AM, Zhang M, Khalili K, Gottlieb RA, Perez JM, Yu JS. Thomas TM, et al. Among authors: murali r. Mol Cancer Res. 2021 Aug;19(8):1375-1388. doi: 10.1158/1541-7786.MCR-20-0086. Epub 2021 Apr 16. Mol Cancer Res. 2021. PMID: 33863814 Free PMC article.
Functional divergence of a bacterial enzyme promotes healthy or acneic skin.
Hajam IA, Katiki M, McNally R, Lázaro-Díez M, Kolar S, Chatterjee A, Gonzalez C, Paulchakrabarti M, Choudhury B, Caldera JR, Desmond T, Tsai CM, Du X, Li H, Murali R, Liu GY. Hajam IA, et al. Among authors: murali r. Nat Commun. 2023 Dec 5;14(1):8061. doi: 10.1038/s41467-023-43833-8. Nat Commun. 2023. PMID: 38052825 Free PMC article.
Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy.
Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. Stanford SM, et al. Among authors: murali r. Sci Adv. 2024 Feb 2;10(5):eadg7887. doi: 10.1126/sciadv.adg7887. Epub 2024 Jan 31. Sci Adv. 2024. PMID: 38295166 Free PMC article.
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Rotinen M, You S, Yang J, Coetzee SG, Reis-Sobreiro M, Huang WC, Huang F, Pan X, Yáñez A, Hazelett DJ, Chu CY, Steadman K, Morrissey CM, Nelson PS, Corey E, Chung LWK, Freedland SJ, Di Vizio D, Garraway IP, Murali R, Knudsen BS, Freeman MR. Rotinen M, et al. Among authors: murali r. Nat Med. 2018 Dec;24(12):1887-1898. doi: 10.1038/s41591-018-0241-1. Epub 2018 Nov 26. Nat Med. 2018. PMID: 30478421 Free PMC article.
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN. Laperle AH, et al. Among authors: murali r. Nat Med. 2020 Feb;26(2):289-299. doi: 10.1038/s41591-019-0739-1. Epub 2020 Jan 27. Nat Med. 2020. PMID: 31988461
526 results