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21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata.
Tropper M, Höhn S, Wolf LS, Fritsch J, Kastner-Detter N, Rieck C, Munkert J, Meitinger N, Lanig H, Kreis W. Tropper M, et al. Among authors: munkert j. Phytochemistry. 2021 Jul;187:112710. doi: 10.1016/j.phytochem.2021.112710. Epub 2021 Apr 28. Phytochemistry. 2021. PMID: 33930670
A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines.
Nolte E, Wach S, Silva IT, Lukat S, Ekici AB, Munkert J, Müller-Uri F, Kreis W, Oliveira Simões CM, Vera J, Wullich B, Taubert H, Lai X. Nolte E, et al. Among authors: munkert j. Oncotarget. 2017 Feb 14;8(7):11676-11691. doi: 10.18632/oncotarget.14644. Oncotarget. 2017. PMID: 28099931 Free PMC article.
Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
Munkert J, Santiago Franco M, Nolte E, Thaís Silva I, Oliveira Castilho R, Melo Ottoni F, Schneider NFZ, Oliveira MC, Taubert H, Bauer W, Andrade SF, Alves RJ, Simões CMO, Braga FC, Kreis W, de Pádua RM. Munkert J, et al. Planta Med. 2017 Aug;83(12-13):1035-1043. doi: 10.1055/s-0043-109557. Epub 2017 May 9. Planta Med. 2017. PMID: 28486743
Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase.
Schneider NFZ, Persich L, Rocha SC, Ramos ACP, Cortes VF, Silva IT, Munkert J, Pádua RM, Kreis W, Taranto AG, Barbosa LA, Braga FC, Simões CMO. Schneider NFZ, et al. Among authors: munkert j. Biomed Pharmacother. 2018 Jan;97:684-696. doi: 10.1016/j.biopha.2017.10.128. Epub 2017 Nov 6. Biomed Pharmacother. 2018. PMID: 29101813
Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+-ATPase inhibition.
Silva IT, Munkert J, Nolte E, Schneider NFZ, Rocha SC, Ramos ACP, Kreis W, Braga FC, de Pádua RM, Taranto AG, Cortes V, Barbosa LA, Wach S, Taubert H, Simões CMO. Silva IT, et al. Among authors: munkert j. Biomed Pharmacother. 2018 Nov;107:464-474. doi: 10.1016/j.biopha.2018.08.028. Epub 2018 Aug 11. Biomed Pharmacother. 2018. PMID: 30107342
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