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Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.
Jian J, Zhao S, Tian Q, Gonzalez-Gugel E, Mundra JJ, Uddin SM, Liu B, Richbourgh B, Brunetti R, Liu CJ. Jian J, et al. Among authors: mundra jj. FEBS Lett. 2013 Nov 1;587(21):3428-36. doi: 10.1016/j.febslet.2013.09.024. Epub 2013 Sep 23. FEBS Lett. 2013. PMID: 24070898 Free PMC article.
Progranulin inhibition of TNFα.
Uddin SM, Mundra JJ, Jian J, Tian Q, Gonzalez-Gugel E, Richbourgh B, Liu CJ. Uddin SM, et al. Among authors: mundra jj. Immunol Cell Biol. 2014 Apr;92(4):299-300. doi: 10.1038/icb.2014.7. Epub 2014 Feb 11. Immunol Cell Biol. 2014. PMID: 24518982 No abstract available.