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Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Kosti P, Opzoomer JW, Larios-Martinez KI, Henley-Smith R, Scudamore CL, Okesola M, Taher MYM, Davies DM, Muliaditan T, Larcombe-Young D, Woodman N, Gillett CE, Thavaraj S, Maher J, Arnold JN. Kosti P, et al. Among authors: muliaditan t. Cell Rep Med. 2021 Apr 9;2(4):100227. doi: 10.1016/j.xcrm.2021.100227. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948568 Free PMC article.
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors.
Muliaditan T, Halim L, Whilding LM, Draper B, Achkova DY, Kausar F, Glover M, Bechman N, Arulappu A, Sanchez J, Flaherty KR, Obajdin J, Grigoriadis K, Antoine P, Larcombe-Young D, Hull CM, Buus R, Gordon P, Grigoriadis A, Davies DM, Schurich A, Maher J. Muliaditan T, et al. Cell Rep Med. 2021 Dec 21;2(12):100457. doi: 10.1016/j.xcrm.2021.100457. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028604 Free PMC article.
Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.
Muliaditan T, Opzoomer JW, Caron J, Okesola M, Kosti P, Lall S, Van Hemelrijck M, Dazzi F, Tutt A, Grigoriadis A, Gillett CE, Madden SF, Burchell JM, Kordasti S, Diebold SS, Spicer JF, Arnold JN. Muliaditan T, et al. Clin Cancer Res. 2018 Apr 1;24(7):1617-1628. doi: 10.1158/1078-0432.CCR-17-2587. Epub 2018 Jan 16. Clin Cancer Res. 2018. PMID: 29339440 Free PMC article.
Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression.
Opzoomer JW, Anstee JE, Dean I, Hill EJ, Bouybayoune I, Caron J, Muliaditan T, Gordon P, Sosnowska D, Nuamah R, Pinder SE, Ng T, Dazzi F, Kordasti S, Withers DR, Lawrence T, Arnold JN. Opzoomer JW, et al. Among authors: muliaditan t. Sci Adv. 2021 Nov 5;7(45):eabg9518. doi: 10.1126/sciadv.abg9518. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34730997 Free PMC article.
LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.
Anstee JE, Feehan KT, Opzoomer JW, Dean I, Muller HP, Bahri M, Cheung TS, Liakath-Ali K, Liu Z, Choy D, Caron J, Sosnowska D, Beatson R, Muliaditan T, An Z, Gillett CE, Lan G, Zou X, Watt FM, Ng T, Burchell JM, Kordasti S, Withers DR, Lawrence T, Arnold JN. Anstee JE, et al. Among authors: muliaditan t. Dev Cell. 2023 Sep 11;58(17):1548-1561.e10. doi: 10.1016/j.devcel.2023.06.006. Epub 2023 Jul 12. Dev Cell. 2023. PMID: 37442140 Free article.
Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.
Sultana MA, Du A, Carow B, Angbjär CM, Weidner JM, Kanatani S, Fuks JM, Muliaditan T, James J, Mansfield IO, Campbell TM, Liu L, Kadri N, Lambert H, Barragan A, Chambers BJ. Sultana MA, et al. Among authors: muliaditan t. Infect Immun. 2017 Sep 20;85(10):e00069-17. doi: 10.1128/IAI.00069-17. Print 2017 Oct. Infect Immun. 2017. PMID: 28760930 Free PMC article.