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Paradoxical activation of oncogenic signaling as a cancer treatment strategy.
Cancer Discov. 2024 Mar 27. doi: 10.1158/2159-8290.CD-23-0216. Online ahead of print.
Cancer Discov. 2024.
PMID: 38533987
Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.
Mulero-Sánchez A, Ramirez CFA, du Chatinier A, Wang H, Koomen SJI, Song JY, de Groot MHP, Lieftink C, Bosma A, Burylo A, van Tellingen O, Beijersbergen RL, Wang C, Akkari L, Bernards R, Mainardi S.
Mulero-Sánchez A, et al.
Mol Oncol. 2023 Jun;17(6):964-980. doi: 10.1002/1878-0261.13377. Epub 2023 Feb 9.
Mol Oncol. 2023.
PMID: 36650715
Free PMC article.
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Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.
Frank KJ, Mulero-Sánchez A, Berninger A, Ruiz-Cañas L, Bosma A, Görgülü K, Wu N, Diakopoulos KN, Kaya-Aksoy E, Ruess DA, Kabacaoğlu D, Schmidt F, Kohlmann L, van Tellingen O, Thijssen B, van de Ven M, Proost N, Kossatz S, Weber WA, Sainz B Jr, Bernards R, Algül H, Lesina M, Mainardi S.
Frank KJ, et al. Among authors: mulero sanchez a.
Cell Rep Med. 2022 Nov 15;3(11):100815. doi: 10.1016/j.xcrm.2022.100815.
Cell Rep Med. 2022.
PMID: 36384095
Free PMC article.
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Genetic and compound screens uncover factors modulating cancer cell response to indisulam.
Pogacar Z, Groot K, Jochems F, Dos Santos Dias M, Mulero-Sánchez A, Morris B, Roosen M, Wardak L, De Conti G, Velds A, Lieftink C, Thijssen B, Beijersbergen RL, Bernards R, Leite de Oliveira R.
Pogacar Z, et al. Among authors: mulero sanchez a.
Life Sci Alliance. 2022 May 9;5(9):e202101348. doi: 10.26508/lsa.202101348. Print 2022 Sep.
Life Sci Alliance. 2022.
PMID: 35534224
Free PMC article.
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Importance of genetic screens in precision oncology.
Mulero-Sánchez A, Pogacar Z, Vecchione L.
Mulero-Sánchez A, et al.
ESMO Open. 2019 May 24;4(3):e000505. doi: 10.1136/esmoopen-2019-000505. eCollection 2019.
ESMO Open. 2019.
PMID: 31231569
Free PMC article.
Review.
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SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Mainardi S, Mulero-Sánchez A, Prahallad A, Germano G, Bosma A, Krimpenfort P, Lieftink C, Steinberg JD, de Wit N, Gonçalves-Ribeiro S, Nadal E, Bardelli A, Villanueva A, Bernards R.
Mainardi S, et al. Among authors: mulero sanchez a.
Nat Med. 2018 Jul;24(7):961-967. doi: 10.1038/s41591-018-0023-9. Epub 2018 May 28.
Nat Med. 2018.
PMID: 29808006
Free article.
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