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Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM. Milbank E, et al. Among authors: mukthavaram r. Pharmacol Res. 2023 Jan;187:106562. doi: 10.1016/j.phrs.2022.106562. Epub 2022 Nov 21. Pharmacol Res. 2023. PMID: 36410673 Free article.
Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.
Rajappan K, Tanis SP, Mukthavaram R, Roberts S, Nguyen M, Tachikawa K, Sagi A, Sablad M, Limphong P, Leu A, Yu H, Chivukula P, Payne JE, Karmali P. Rajappan K, et al. Among authors: mukthavaram r. J Med Chem. 2020 Nov 12;63(21):12992-13012. doi: 10.1021/acs.jmedchem.0c01407. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119286
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M. Hirunagi T, et al. Among authors: mukthavaram r. Mol Ther Nucleic Acids. 2021 Feb 15;24:1-10. doi: 10.1016/j.omtn.2021.02.007. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33738134 Free PMC article.
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
Wolff G, Sakurai M, Mhamane A, Troullinaki M, Maida A, Deligiannis IK, Yin K, Weber P, Morgenstern J, Wieder A, Kwon Y, Sekar R, Zeigerer A, Roden M, Blüher M, Volk N, Poth T, Hackert T, Wiedmann L, De Angelis Rigotti F, Rodriguez-Vita J, Fischer A, Mukthavaram R, Limphong P, Tachikawa K, Karmali P, Payne J, Chivukula P, Ekim-Üstünel B, Martinez-Jimenez CP, Szendrödi J, Nawroth P, Herzig S. Wolff G, et al. Among authors: mukthavaram r. Mol Metab. 2022 Jun;60:101487. doi: 10.1016/j.molmet.2022.101487. Epub 2022 Apr 1. Mol Metab. 2022. PMID: 35378329 Free PMC article.
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice.
Comas F, Díaz-Trelles R, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Latorre J, Ortega F, Arnoriaga-Rodriguez M, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, Giralt M, López M, Fernández-Real JM, Moreno-Navarrete JM. Comas F, et al. Among authors: mukthavaram r. Biomed Pharmacother. 2022 Jul;151:113156. doi: 10.1016/j.biopha.2022.113156. Epub 2022 May 25. Biomed Pharmacother. 2022. PMID: 35643066 Free article.
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation.
Latorre J, Díaz-Trelles R, Comas F, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Ortega F, Castells-Nobau A, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, López M, Giralt M, Fernández-Real JM, Moreno-Navarrete JM. Latorre J, et al. Among authors: mukthavaram r. Mol Ther Nucleic Acids. 2022 Aug 5;29:599-613. doi: 10.1016/j.omtn.2022.08.003. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090751 Free PMC article.
Efficacy increase of lipid nanoparticles in vivo by inclusion of bis(monoacylglycerol)phosphate.
Sagi A, Mukthavaram R, Recatto R, Hong H, Davis M, Trelles RD, El-Mecharrafie N, Acharya G, Gomez A, Leu A, Tachikawa K, Sacchetti C, Soontornniyomkij B, Rajappan K, Karmali P, Chivakula P. Sagi A, et al. Among authors: mukthavaram r. Nanomedicine (Lond). 2022 Aug;17(20):1399-1410. doi: 10.2217/nnm-2022-0002. Epub 2022 Oct 18. Nanomedicine (Lond). 2022. PMID: 36255044
29 results