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Aminothiazoles: Hit to lead development to identify antileishmanial agents.
Bhuniya D, Mukkavilli R, Shivahare R, Launay D, Dere RT, Deshpande A, Verma A, Vishwakarma P, Moger M, Pradhan A, Pati H, Gopinath VS, Gupta S, Puri SK, Martin D. Bhuniya D, et al. Among authors: mukkavilli r. Eur J Med Chem. 2015 Sep 18;102:582-93. doi: 10.1016/j.ejmech.2015.08.013. Epub 2015 Aug 11. Eur J Med Chem. 2015. PMID: 26318065
In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis.
Mukkavilli R, Pinjari J, Patel B, Sengottuvelan S, Mondal S, Gadekar A, Verma M, Patel J, Pothuri L, Chandrashekar G, Koiram P, Harisudhan T, Moinuddin A, Launay D, Vachharajani N, Ramanathan V, Martin D. Mukkavilli R, et al. Eur J Pharm Sci. 2014 Dec 18;65:147-55. doi: 10.1016/j.ejps.2014.09.006. Epub 2014 Sep 27. Eur J Pharm Sci. 2014. PMID: 25261338 Free article.
Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.
Henary M, Narayana L, Ahad S, Gundala SR, Mukkavilli R, Sharma V, Owens EA, Yadav Y, Nagaraju M, Hamelberg D, Tandon V, Panda D, Aneja R. Henary M, et al. Among authors: mukkavilli r. Biochem Pharmacol. 2014 Nov 15;92(2):192-205. doi: 10.1016/j.bcp.2014.07.020. Epub 2014 Aug 11. Biochem Pharmacol. 2014. PMID: 25124704 Free PMC article.
Noscapine recirculates enterohepatically and induces self-clearance.
Mukkavilli R, Gundala SR, Yang C, Jadhav GR, Vangala S, Reid MD, Aneja R. Mukkavilli R, et al. Eur J Pharm Sci. 2015 Sep 18;77:90-9. doi: 10.1016/j.ejps.2015.05.026. Epub 2015 May 28. Eur J Pharm Sci. 2015. PMID: 26026989 Free PMC article.
16 results