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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.
Woess K, Macho-Maschler S, Van Ingen Schenau DS, Butler M, Lassnig C, Valcanover D, Poelzl A, Meissl K, Maurer B, Brandstoetter T, Vogl C, Koren A, Kubicek S, Orlova A, Moriggl R, Strobl B, Sexl V, Van Leeuwen FN, Kuiper RP, Mueller M. Woess K, et al. Among authors: mueller m. Haematologica. 2023 Apr 1;108(4):993-1005. doi: 10.3324/haematol.2021.279848. Haematologica. 2023. PMID: 35021603 Free PMC article.
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Porpaczy E, Tripolt S, Hoelbl-Kovacic A, Gisslinger B, Bago-Horvath Z, Casanova-Hevia E, Clappier E, Decker T, Fajmann S, Fux DA, Greiner G, Gueltekin S, Heller G, Herkner H, Hoermann G, Kiladjian JJ, Kolbe T, Kornauth C, Krauth MT, Kralovics R, Muellauer L, Mueller M, Prchal-Murphy M, Putz EM, Raffoux E, Schiefer AI, Schmetterer K, Schneckenleithner C, Simonitsch-Klupp I, Skrabs C, Sperr WR, Staber PB, Strobl B, Valent P, Jaeger U, Gisslinger H, Sexl V. Porpaczy E, et al. Among authors: mueller m. Blood. 2018 Aug 16;132(7):694-706. doi: 10.1182/blood-2017-10-810739. Epub 2018 Jun 14. Blood. 2018. PMID: 29907599 Free PMC article.
Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.
Kollmann S, Grundschober E, Maurer B, Warsch W, Grausenburger R, Edlinger L, Huuhtanen J, Lagger S, Hennighausen L, Valent P, Decker T, Strobl B, Mueller M, Mustjoki S, Hoelbl-Kovacic A, Sexl V. Kollmann S, et al. Among authors: mueller m. Leukemia. 2019 Jul;33(7):1583-1597. doi: 10.1038/s41375-018-0369-5. Epub 2019 Jan 24. Leukemia. 2019. PMID: 30679796 Free PMC article.
TYK2 licenses non-canonical inflammasome activation during endotoxemia.
Poelzl A, Lassnig C, Tangermann S, Hromadová D, Reichart U, Gawish R, Mueller K, Moriggl R, Linkermann A, Glösmann M, Kenner L, Mueller M, Strobl B. Poelzl A, et al. Among authors: mueller m, mueller k. Cell Death Differ. 2021 Feb;28(2):748-763. doi: 10.1038/s41418-020-00621-x. Epub 2020 Sep 14. Cell Death Differ. 2021. PMID: 32929218 Free PMC article.
Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Sukhbaatar N, Schöller M, Fritsch SD, Linke M, Horer S, Träger M, Mazić M, Forisch S, Gonzales K, Kahler JP, Binder C, Lassnig C, Strobl B, Müller M, Scheiber-Mojdehkar B, Gundacker C, Dabsch S, Kain R, Hengstschläger M, Verhelst SHL, Weiss G, Theurl I, Weichhart T. Sukhbaatar N, et al. Blood. 2023 Jun 8;141(23):2878-2890. doi: 10.1182/blood.2022016632. Blood. 2023. PMID: 37018657 Free PMC article.
Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer.
Friedbichler K, Themanns M, Mueller KM, Schlederer M, Kornfeld JW, Terracciano LM, Kozlov AV, Haindl S, Kenner L, Kolbe T, Mueller M, Snibson KJ, Heim MH, Moriggl R. Friedbichler K, et al. Among authors: mueller m, mueller km. Hepatology. 2012 Mar;55(3):941-52. doi: 10.1002/hep.24765. Epub 2012 Jan 13. Hepatology. 2012. PMID: 22031092
Bacterial polyphosphates interfere with the innate host defense to infection.
Roewe J, Stavrides G, Strueve M, Sharma A, Marini F, Mann A, Smith SA, Kaya Z, Strobl B, Mueller M, Reinhardt C, Morrissey JH, Bosmann M. Roewe J, et al. Among authors: mueller m. Nat Commun. 2020 Aug 12;11(1):4035. doi: 10.1038/s41467-020-17639-x. Nat Commun. 2020. PMID: 32788578 Free PMC article.
Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection.
Pezoldt J, Wiechers C, Erhard F, Rand U, Bulat T, Beckstette M, Brendolan A, Huehn J, Kalinke U, Mueller M, Strobl B, Deplancke B, Čičin-Šain L, Sitnik KM. Pezoldt J, et al. Among authors: mueller m. Commun Biol. 2021 Dec 2;4(1):1355. doi: 10.1038/s42003-021-02882-9. Commun Biol. 2021. PMID: 34857864 Free PMC article.
2,707 results