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Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.
Reddy BK, Landge S, Ravishankar S, Patil V, Shinde V, Tantry S, Kale M, Raichurkar A, Menasinakai S, Mudugal NV, Ambady A, Ghosh A, Tunduguru R, Kaur P, Singh R, Kumar N, Bharath S, Sundaram A, Bhat J, Sambandamurthy VK, Björkelid C, Jones TA, Das K, Bandodkar B, Malolanarasimhan K, Mukherjee K, Ramachandran V. Reddy BK, et al. Among authors: mudugal nv. Antimicrob Agents Chemother. 2014 Jun;58(6):3312-26. doi: 10.1128/AAC.00140-14. Epub 2014 Mar 31. Antimicrob Agents Chemother. 2014. PMID: 24687493 Free PMC article.
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli.
Hameed P S, Manjrekar P, Chinnapattu M, Humnabadkar V, Shanbhag G, Kedari C, Mudugal NV, Ambady A, de Jonge BL, Sadler C, Paul B, Sriram S, Kaur P, Guptha S, Raichurkar A, Fleming P, Eyermann CJ, McKinney DC, Sambandamurthy VK, Panda M, Ravishankar S. Hameed P S, et al. Among authors: mudugal nv. ACS Chem Biol. 2014 Oct 17;9(10):2274-82. doi: 10.1021/cb500360c. Epub 2014 Aug 5. ACS Chem Biol. 2014. PMID: 25035921
Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Ravishankar S, Ambady A, Awasthy D, Mudugal NV, Menasinakai S, Jatheendranath S, Guptha S, Sharma S, Balakrishnan G, Nandishaiah R, Ramachandran V, Eyermann CJ, Reck F, Rudrapatna S, Sambandamurthy VK, Sharma UK. Ravishankar S, et al. Among authors: mudugal nv. Tuberculosis (Edinb). 2015 Sep;95(5):589-98. doi: 10.1016/j.tube.2015.05.004. Epub 2015 May 27. Tuberculosis (Edinb). 2015. PMID: 26073894
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
Tantry SJ, Markad SD, Shinde V, Bhat J, Balakrishnan G, Gupta AK, Ambady A, Raichurkar A, Kedari C, Sharma S, Mudugal NV, Narayan A, Naveen Kumar CN, Nanduri R, Bharath S, Reddy J, Panduga V, Prabhakar KR, Kandaswamy K, Saralaya R, Kaur P, Dinesh N, Guptha S, Rich K, Murray D, Plant H, Preston M, Ashton H, Plant D, Walsh J, Alcock P, Naylor K, Collier M, Whiteaker J, McLaughlin RE, Mallya M, Panda M, Rudrapatna S, Ramachandran V, Shandil R, Sambandamurthy VK, Mdluli K, Cooper CB, Rubin H, Yano T, Iyer P, Narayanan S, Kavanagh S, Mukherjee K, Balasubramanian V, Hosagrahara VP, Solapure S, Ravishankar S, Hameed P S. Tantry SJ, et al. Among authors: mudugal nv. J Med Chem. 2017 Feb 23;60(4):1379-1399. doi: 10.1021/acs.jmedchem.6b01358. Epub 2017 Feb 3. J Med Chem. 2017. PMID: 28075132
An IPTG Inducible Conditional Expression System for Mycobacteria.
Ravishankar S, Ambady A, Ramu H, Mudugal NV, Tunduguru R, Anbarasu A, Sharma UK, Sambandamurthy VK, Ramaiah S. Ravishankar S, et al. Among authors: mudugal nv. PLoS One. 2015 Aug 6;10(8):e0134562. doi: 10.1371/journal.pone.0134562. eCollection 2015. PLoS One. 2015. PMID: 26247874 Free PMC article.