Moutinho M - Search Results

1

INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.

Lin PB, Tsai AP, Soni D, Lee-Gosselin A, Moutinho M, Puntambekar SS, Landreth GE, Lamb BT, Oblak AL. Lin PB, et al. Among authors: moutinho m. Alzheimers Dement. 2023 Jun;19(6):2528-2537. doi: 10.1002/alz.12849. Epub 2022 Dec 16. Alzheimers Dement. 2023. PMID: 36524682

2

Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.

Nunes MJ, Moutinho M, Gama MJ, Rodrigues CM, Rodrigues E. Nunes MJ, et al. Among authors: moutinho m. PLoS One. 2013;8(1):e53394. doi: 10.1371/journal.pone.0053394. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326422 Free PMC article.

3

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.

Moutinho M, Nunes MJ, Gomes AQ, Gama MJ, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Rodrigues E. Moutinho M, et al. Mol Neurobiol. 2015;51(3):1489-503. doi: 10.1007/s12035-014-8828-0. Epub 2014 Aug 2. Mol Neurobiol. 2015. PMID: 25084760

4

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Ruas JL, Rodrigues E. Moutinho M, et al. Sci Rep. 2016 Aug 5;6:30928. doi: 10.1038/srep30928. Sci Rep. 2016. PMID: 27491694 Free PMC article.

5

Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

Milagre I, Olin M, Nunes MJ, Moutinho M, Lövgren-Sandblom A, Gama MJ, Björkhem I, Rodrigues E. Milagre I, et al. Among authors: moutinho m. Neurochem Int. 2012 Jan;60(2):192-8. doi: 10.1016/j.neuint.2011.12.003. Epub 2011 Dec 13. Neurochem Int. 2012. PMID: 22185844

6

The mevalonate pathway in neurons: It's not just about cholesterol.

Moutinho M, Nunes MJ, Rodrigues E. Moutinho M, et al. Exp Cell Res. 2017 Nov 1;360(1):55-60. doi: 10.1016/j.yexcr.2017.02.034. Epub 2017 Feb 21. Exp Cell Res. 2017. PMID: 28232115 Review.

7

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond.

Moutinho M, Nunes MJ, Rodrigues E. Moutinho M, et al. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1911-1920. doi: 10.1016/j.bbalip.2016.09.011. Epub 2016 Sep 20. Biochim Biophys Acta. 2016. PMID: 27663182 Review.

8

Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter.

Milagre I, Nunes MJ, Castro-Caldas M, Moutinho M, Gama MJ, Rodrigues E. Milagre I, et al. Among authors: moutinho m. J Neurochem. 2012 Jan;120(2):220-9. doi: 10.1111/j.1471-4159.2011.07577.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22060190 Free article.

9

Therapeutic potential of nuclear receptor agonists in Alzheimer's disease.

Moutinho M, Landreth GE. Moutinho M, et al. J Lipid Res. 2017 Oct;58(10):1937-1949. doi: 10.1194/jlr.R075556. Epub 2017 Mar 6. J Lipid Res. 2017. PMID: 28264880 Free PMC article. Review.

10

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. Cheng-Hathaway PJ, et al. Among authors: moutinho m. Mol Neurodegener. 2018 Jun 1;13(1):29. doi: 10.1186/s13024-018-0262-8. Mol Neurodegener. 2018. PMID: 29859094 Free PMC article.

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