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Page 1
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.
Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Gaiti F, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA. Nam AS, et al. Among authors: mouhieddine th. Nat Genet. 2022 Oct;54(10):1514-1526. doi: 10.1038/s41588-022-01179-9. Epub 2022 Sep 22. Nat Genet. 2022. PMID: 36138229 Free PMC article.
Established and Novel Prognostic Biomarkers in Multiple Myeloma.
Bustoros M, Mouhieddine TH, Detappe A, Ghobrial IM. Bustoros M, et al. Among authors: mouhieddine th. Am Soc Clin Oncol Educ Book. 2017;37:548-560. doi: 10.1200/EDBK_175175. Am Soc Clin Oncol Educ Book. 2017. PMID: 28561668 Free article. Review.
Monoclonal gammopathy of undetermined significance.
Mouhieddine TH, Weeks LD, Ghobrial IM. Mouhieddine TH, et al. Blood. 2019 Jun 6;133(23):2484-2494. doi: 10.1182/blood.2019846782. Epub 2019 Apr 22. Blood. 2019. PMID: 31010848 Free article. Review.
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant.
Mouhieddine TH, Sperling AS, Redd R, Park J, Leventhal M, Gibson CJ, Manier S, Nassar AH, Capelletti M, Huynh D, Bustoros M, Sklavenitis-Pistofidis R, Tahri S, Hornburg K, Dumke H, Itani MM, Boehner CJ, Liu CJ, AlDubayan SH, Reardon B, Van Allen EM, Keats JJ, Stewart C, Mehr S, Auclair D, Schlossman RL, Munshi NC, Anderson KC, Steensma DP, Laubach JP, Richardson PG, Ritz J, Ebert BL, Soiffer RJ, Trippa L, Getz G, Neuberg DS, Ghobrial IM. Mouhieddine TH, et al. Nat Commun. 2020 Jun 12;11(1):2996. doi: 10.1038/s41467-020-16805-5. Nat Commun. 2020. PMID: 32533060 Free PMC article.
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.
Zavidij O, Haradhvala NJ, Mouhieddine TH, Sklavenitis-Pistofidis R, Cai S, Reidy M, Rahmat M, Flaifel A, Ferland B, Su NK, Agius MP, Park J, Manier S, Bustoros M, Huynh D, Capelletti M, Berrios B, Liu CJ, He MX, Braggio E, Fonseca R, Maruvka YE, Guerriero JL, Goldman M, Van Allen EM, McCarroll SA, Azzi J, Getz G, Ghobrial IM. Zavidij O, et al. Among authors: mouhieddine th. Nat Cancer. 2020 May;1(5):493-506. doi: 10.1038/s43018-020-0053-3. Epub 2020 Apr 27. Nat Cancer. 2020. PMID: 33409501 Free PMC article.
Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia.
Tahri S, Mouhieddine TH, Redd R, Lampe L, Nilsson KI, El-Khoury H, Su NK, Nassar AH, Adib E, Bindra G, Abou Alaiwi S, Trippa L, Steensma DP, Castillo JJ, Treon SP, Ghobrial IM, Sperling AS. Tahri S, et al. Among authors: mouhieddine th. Blood Adv. 2022 Apr 12;6(7):2230-2235. doi: 10.1182/bloodadvances.2021004926. Blood Adv. 2022. PMID: 34847227 Free PMC article.
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.
Sklavenitis-Pistofidis R, Aranha MP, Redd RA, Baginska J, Haradhvala NJ, Hallisey M, Dutta AK, Savell A, Varmeh S, Heilpern-Mallory D, Ujwary S, Zavidij O, Aguet F, Su NK, Lightbody ED, Bustoros M, Tahri S, Mouhieddine TH, Wu T, Flechon L, Anand S, Rosenblatt JM, Zonder J, Vredenburgh JJ, Boruchov A, Bhutani M, Usmani SZ, Matous J, Yee AJ, Jakubowiak A, Laubach J, Manier S, Nadeem O, Richardson P, Badros AZ, Mateos MV, Trippa L, Getz G, Ghobrial IM. Sklavenitis-Pistofidis R, et al. Among authors: mouhieddine th. Cancer Cell. 2022 Nov 14;40(11):1358-1373.e8. doi: 10.1016/j.ccell.2022.10.017. Cancer Cell. 2022. PMID: 36379208 Free PMC article.
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis.
Boiarsky R, Haradhvala NJ, Alberge JB, Sklavenitis-Pistofidis R, Mouhieddine TH, Zavidij O, Shih MC, Firer D, Miller M, El-Khoury H, Anand SK, Aguet F, Sontag D, Ghobrial IM, Getz G. Boiarsky R, et al. Among authors: mouhieddine th. Nat Commun. 2022 Nov 17;13(1):7040. doi: 10.1038/s41467-022-33944-z. Nat Commun. 2022. PMID: 36396631 Free PMC article.
Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma.
Mouhieddine TH, Nzerem C, Redd R, Dunford A, Leventhal M, Sklavenitis-Pistofidis R, Tahri S, El-Khoury H, Steensma DP, Ebert BL, Soiffer RJ, Keats JJ, Mehr S, Auclair D, Ghobrial IM, Sperling AS, Stewart C, Getz G. Mouhieddine TH, et al. Cancer Res Commun. 2023 Dec 18;3(12):2560-2571. doi: 10.1158/2767-9764.CRC-23-0093. Cancer Res Commun. 2023. PMID: 38019104 Free PMC article.
54 results